Interleukin-13 receptor

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interleukin 13 receptor, alpha 1
Identifiers
Symbol IL13RA1
Alt. symbols IL-13Ra, NR4, CD213a1
Entrez 3597
HUGO 5974
OMIM 300119
RefSeq NM_001560
UniProt P78552
Other data
Locus Chr. X q24
interleukin 13 receptor, alpha 2
Identifiers
Symbol IL13RA2
Alt. symbols IL-13R, IL13BP, CD213a2
Entrez 3598
HUGO 5975
OMIM 300130
RefSeq NM_000640
UniProt Q14627
Other data
Locus Chr. X q13.1-q28
interleukin 4 receptor
Identifiers
Symbol IL4R
Alt. symbols IL4RA; CD124
Entrez 3566
HUGO 6015
OMIM 147781
RefSeq NM_000418
UniProt Q9H186
Other data
Locus Chr. 16 p12.1-11.2

The interleukin-13 receptor is a type I cytokine receptor, binding Interleukin-13. It consists of two subunits, encoded by IL13RA1 and IL4R, respectively.[1][2] These two genes encode the proteins IL-13Rα1 and IL-4Rα. These form a dimer with IL-13 binding to the IL-13Rα1 chain and IL-4Rα stabilises this interaction. This IL-13 receptor can also instigate IL-4 signalling. In both cases this occurs via activation of the Janus kinase (JAK)/Signal Transducer and Activator of Transcription (STAT) pathway, resulting in phosphorylation of STAT6. Phosphorylated STAT6 dimerises and acts as a transcription factor activating many genes, such as eotaxin.[citation needed]

There is also another receptor that can bind IL-13: IL-13Rα2 encoded by the IL13RA2 gene. This binds IL-13 with very high affinity (and can therefore sequester it) but does not allow IL-4 binding. It acts as a negative regulator of both IL-13 and IL-4, however the mechanism of this is still undetermined.[3]

References[edit]

  1. ^ Murata T, Obiri NI, Puri RK (1998). "Structure of and signal transduction through interleukin-4 and interleukin-13 receptors (review)". Int. J. Mol. Med. 1 (3): 551–7. doi:10.3892/ijmm.1.3.551. PMID 9852261. 
  2. ^ Chomarat P, Banchereau J (1998). "Interleukin-4 and interleukin-13: their similarities and discrepancies". Int. Rev. Immunol. 17 (1–4): 1–52. doi:10.3109/08830189809084486. PMID 9914942. 
  3. ^ Seyfizadeh, N., Seyfizadeh, N., Babaloo, Z. (2014). "Interleukin-13 as an Important Mediator: A Review on its Roles in Some Human Diseases", Iranian Journal of Allergy, Asthma and Immunology, In Press.

External links[edit]