Interleukin-21 receptor

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Interleukin 21 receptor
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols IL21R ; CD360; NILR
External IDs OMIM605383 MGI1890475 HomoloGene11040 GeneCards: IL21R Gene
RNA expression pattern
PBB GE IL21R 219971 at tn.png
PBB GE IL21R 221658 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 50615 60504
Ensembl ENSG00000103522 ENSMUSG00000030745
UniProt Q9HBE5 Q9JHX3
RefSeq (mRNA) NM_021798 NM_021887
RefSeq (protein) NP_068570 NP_068687
Location (UCSC) Chr 16:
27.41 – 27.46 Mb
Chr 7:
125.6 – 125.63 Mb
PubMed search [1] [2]

Interleukin 21 receptor is a type I cytokine receptor. IL21R is its human gene.[1]

The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2 (IL2), interleukin 7 (IL7) and interleukin 15 (IL15). This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants encoding the same protein have been described.[1]

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