Interleukin 10 receptor, alpha subunit

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Interleukin 10 receptor, alpha
Protein IL10RA PDB 1j7v.png
PDB rendering based on 1j7v.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols IL10RA ; CD210; CD210a; CDW210A; HIL-10R; IL-10R1; IL10R
External IDs OMIM146933 MGI96538 HomoloGene1196 GeneCards: IL10RA Gene
RNA expression pattern
PBB GE IL10RA 204912 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3587 16154
Ensembl ENSG00000110324 ENSMUSG00000032089
UniProt Q13651 Q61727
RefSeq (mRNA) NM_001558 NM_008348
RefSeq (protein) NP_001549 NP_032374
Location (UCSC) Chr 11:
117.86 – 117.87 Mb
Chr 9:
45.25 – 45.27 Mb
PubMed search [1] [2]

Interleukin 10 receptor, alpha subunit is a subunit for the interleukin-10 receptor. IL10RA, is its human gene.

IL10RA has also recently been designated CDW210A (cluster of differentiation W210A).

The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases.[1]

Interactions[edit]

Interleukin 10 receptor, alpha subunit has been shown to interact with Interleukin 10[2][3][4][5][6] and Janus kinase 1.[7][8]

References[edit]

  1. ^ "Entrez Gene: IL10RA interleukin 10 receptor, alpha". 
  2. ^ Ho, A S; Liu Y; Khan T A; Hsu D H; Bazan J F; Moore K W (December 1993). "A receptor for interleukin 10 is related to interferon receptors". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 90 (23): 11267–71. doi:10.1073/pnas.90.23.11267. ISSN 0027-8424. PMC 47963. PMID 8248239. 
  3. ^ Josephson, K; Logsdon N J; Walter M R (July 2001). "Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site". Immunity (United States) 15 (1): 35–46. doi:10.1016/S1074-7613(01)00169-8. ISSN 1074-7613. PMID 11485736. 
  4. ^ Tan, J C; Braun S; Rong H; DiGiacomo R; Dolphin E; Baldwin S; Narula S K; Zavodny P J; Chou C C (May 1995). "Characterization of recombinant extracellular domain of human interleukin-10 receptor". J. Biol. Chem. (UNITED STATES) 270 (21): 12906–11. doi:10.1074/jbc.270.21.12906. ISSN 0021-9258. PMID 7759550. 
  5. ^ Josephson, K; McPherson D T; Walter M R (December 2001). "Purification, crystallization and preliminary X-ray diffraction of a complex between IL-10 and soluble IL-10R1". Acta Crystallogr. D Biol. Crystallogr. (Denmark) 57 (Pt 12): 1908–11. doi:10.1107/S0907444901016249. ISSN 0907-4449. PMID 11717514. 
  6. ^ Hoover, D M; Schalk-Hihi C; Chou C C; Menon S; Wlodawer A; Zdanov A (May 1999). "Purification of receptor complexes of interleukin-10 stoichiometry and the importance of deglycosylation in their crystallization". Eur. J. Biochem. (GERMANY) 262 (1): 134–41. doi:10.1046/j.1432-1327.1999.00363.x. ISSN 0014-2956. PMID 10231374. 
  7. ^ Usacheva, Anna; Sandoval Raudel; Domanski Paul; Kotenko Sergei V; Nelms Keats; Goldsmith Mark A; Colamonici Oscar R (December 2002). "Contribution of the Box 1 and Box 2 motifs of cytokine receptors to Jak1 association and activation". J. Biol. Chem. (United States) 277 (50): 48220–6. doi:10.1074/jbc.M205757200. ISSN 0021-9258. PMID 12374810. 
  8. ^ Usacheva, Anna; Kotenko Sergei; Witte Michael M; Colamonici Oscar R (August 2002). "Two distinct domains within the N-terminal region of Janus kinase 1 interact with cytokine receptors". J. Immunol. (United States) 169 (3): 1302–8. doi:10.4049/jimmunol.169.3.1302. ISSN 0022-1767. PMID 12133952. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.