Interleukin 19

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Interleukin 19
IL19 Crystal Structure.png
Crystal structure of human IL-19 based on PDB 1N1F
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols IL19 ; IL-10C; MDA1; NG.1; ZMDA1
External IDs OMIM605687 HomoloGene17813 GeneCards: IL19 Gene
Orthologs
Species Human Mouse
Entrez 29949 329244
Ensembl ENSG00000142224 ENSMUSG00000016524
UniProt Q9UHD0 Q8CJ70
RefSeq (mRNA) NM_013371 NM_001009940
RefSeq (protein) NP_037503 NP_001009940
Location (UCSC) Chr 1:
206.97 – 207.02 Mb
Chr 1:
130.93 – 130.94 Mb
PubMed search [1] [2]

Interleukin 19 is a protein that in humans is encoded by the IL19 gene.[1]

Function[edit]

The protein encoded by this gene is a cytokine that belongs to the IL-10 cytokine subfamily. This cytokine is found to be preferentially expressed in monocytes. It can bind the interleukin-20 receptor complex and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). A similar cytokine in mouse is reported to up-regulate the expression of IL6 and TNF-alpha and induce apoptosis, which suggests a role of this cytokine in inflammatory responses. Alternatively spliced transcript variants encoding the distinct isoforms have been described.[1]

Interleukin-19 is a cytokine that belongs to the IL-10 family of cytokines along with several other interleukins including IL-10, IL-20, IL-22, IL-24, IL-26, and several virus-encoded cytokines. It signals through the same cell surface receptor (IL-20R) that is used by IL-20 and IL-24. The IL-19 gene is expressed in resting monocytes and B cells. It is up-regulated in monocytes following stimulation with granulocyte-macrophage colony-stimulating factor (GM-CSF) or lipopolysaccharide.[2]

References[edit]

  1. ^ a b "Entrez Gene: Interleukin 19". 
  2. ^ Chang C, Magracheva E, Kozlov S, Fong S, Tobin G, Kotenko S, Wlodawer A, Zdanov A (January 2003). "Crystal structure of interleukin-19 defines a new subfamily of helical cytokines". J. Biol. Chem. 278 (5): 3308–13. doi:10.1074/jbc.M208602200. PMID 12403790. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.