Interleukin 1 receptor, type I

Interleukin 1 receptor, type I
PDB rendering based on 1g0y.
Available structures PDB 1G0Y, 1IRA, 1ITB
Identifiers
Symbols	IL1R1; CD121A; D2S1473; IL-1R-alpha; IL1R; IL1RA; P80
External IDs	OMIM: 147810 MGI: 96545 HomoloGene: 677 GeneCards: IL1R1 Gene
Gene Ontology Molecular function • signal transducer activity • transmembrane receptor activity • interleukin-1 receptor activity • interleukin-1, Type I, activating receptor activity • platelet-derived growth factor receptor binding • protein binding Cellular component • plasma membrane • plasma membrane • integral to plasma membrane • cell surface • membrane Biological process • immune response • cell surface receptor linked signaling pathway • ovulation • innate immune response • interleukin-1-mediated signaling pathway • interleukin-1-mediated signaling pathway • response to interleukin-1 • response to nitric oxide Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3554	16177
Ensembl	ENSG00000115594	ENSMUSG00000026072
UniProt	P14778	Q32MH0
RefSeq (mRNA)	NM_000877	XM_979865
RefSeq (protein)	NP_000868	XP_984959
Location (UCSC)	Chr 2: 102.68 – 102.8 Mb	Chr 1: 40.28 – 40.37 Mb
PubMed search	[1]	[2]

Interleukin 1 receptor, type I (IL1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. IL1R1 also denotes its human gene.

The protein encoded by this gene is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein is a receptor for interleukin 1 alpha (IL1A), interleukin 1 beta (IL1B), and interleukin 1 receptor antagonist (IL1RA). It is an important mediator involved in many cytokine induced immune and inflammatory responses. This gene along with interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 2 (IL1RL2), and interleukin 1 receptor-like 1 (IL1RL1) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12.

Interactions

Interleukin 1 receptor, type I has been shown to interact with PIK3R1, Myd88 and IL1RAP.

See also

• Cluster of differentiation
• Interleukin 1 receptor, type II

Further reading

• Copeland NG, Silan CM, Kingsley DM, et al. (1991). "Chromosomal location of murine and human IL-1 receptor genes.". Genomics 9 (1): 44–50. doi:10.1016/0888-7543(91)90219-5. PMID 1672292. 
• McMahan CJ, Slack JL, Mosley B, et al. (1991). "A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types.". EMBO J. 10 (10): 2821–32. PMC 452992. PMID 1833184. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=452992. 
• Uhl J, Newton RC, Giri JG, et al. (1989). "Identification of IL-1 receptors on human monocytes.". J. Immunol. 142 (5): 1576–81. PMID 2521881. 
• Sims JE, Acres RB, Grubin CE, et al. (1989). "Cloning the interleukin 1 receptor from human T cells.". Proc. Natl. Acad. Sci. U.S.A. 86 (22): 8946–50. doi:10.1073/pnas.86.22.8946. PMC 298407. PMID 2530587. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=298407. 
• Chua AO, Gubler U (1990). "Sequence of the cDNA for the human fibroblast type interleukin-1 receptor.". Nucleic Acids Res. 17 (23): 10114. doi:10.1093/nar/17.23.10114. PMC 335251. PMID 2532321. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=335251. 
• Dower SK, Kronheim SR, Hopp TP, et al. (1987). "The cell surface receptors for interleukin-1 alpha and interleukin-1 beta are identical.". Nature 324 (6094): 266–8. doi:10.1038/324266a0. PMID 2946959. 
• Rautonen N, Rautonen J, Martin NL, Wara DW (1995). "HIV-1 Tat induces cytokine synthesis by uninfected mononuclear cells.". AIDS 8 (10): 1504–6. doi:10.1097/00002030-199410000-00023. PMID 7818827. 
• Vigers GP, Anderson LJ, Caffes P, Brandhuber BJ (1997). "Crystal structure of the type-I interleukin-1 receptor complexed with interleukin-1beta.". Nature 386 (6621): 190–4. doi:10.1038/386190a0. PMID 9062193. 
• Schreuder H, Tardif C, Trump-Kallmeyer S, et al. (1997). "A new cytokine-receptor binding mode revealed by the crystal structure of the IL-1 receptor with an antagonist.". Nature 386 (6621): 194–200. doi:10.1038/386194a0. PMID 9062194. 
• Rameshwar P, Poddar A, Zhu G, Gascón P (1997). "Receptor induction regulates the synergistic effects of substance P with IL-1 and platelet-derived growth factor on the proliferation of bone marrow fibroblasts.". J. Immunol. 158 (7): 3417–24. PMID 9120302. 
• Reddy SA, Huang JH, Liao WS (1997). "Phosphatidylinositol 3-kinase in interleukin 1 signaling. Physical interaction with the interleukin 1 receptor and requirement in NFkappaB and AP-1 activation.". J. Biol. Chem. 272 (46): 29167–73. doi:10.1074/jbc.272.46.29167. PMID 9360994. 
• Huang J, Gao X, Li S, Cao Z (1998). "Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein.". Proc. Natl. Acad. Sci. U.S.A. 94 (24): 12829–32. doi:10.1073/pnas.94.24.12829. PMC 24223. PMID 9371760. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=24223. 
• Muzio M, Ni J, Feng P, Dixit VM (1997). "IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling.". Science 278 (5343): 1612–5. doi:10.1126/science.278.5343.1612. PMID 9374458. 
• Dale M, Nicklin MJ (1999). "Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q.". Genomics 57 (1): 177–9. doi:10.1006/geno.1999.5767. PMID 10191101. 
• Sizemore N, Leung S, Stark GR (1999). "Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/RelA subunit.". Mol. Cell. Biol. 19 (7): 4798–805. PMC 84278. PMID 10373529. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=84278. 
• Burns K, Clatworthy J, Martin L, et al. (2000). "Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor.". Nat. Cell Biol. 2 (6): 346–51. doi:10.1038/35014038. PMID 10854325. 
• Vigers GP, Dripps DJ, Edwards CK, Brandhuber BJ (2001). "X-ray crystal structure of a small antagonist peptide bound to interleukin-1 receptor type 1.". J. Biol. Chem. 275 (47): 36927–33. doi:10.1074/jbc.M006071200. PMID 10903327. 
• Lin H, Ho AS, Haley-Vicente D, et al. (2001). "Cloning and characterization of IL-1HY2, a novel interleukin-1 family member.". J. Biol. Chem. 276 (23): 20597–602. doi:10.1074/jbc.M010095200. PMID 11278614. 
• Joos L, McIntyre L, Ruan J, et al. (2001). "Association of IL-1beta and IL-1 receptor antagonist haplotypes with rate of decline in lung function in smokers.". Thorax 56 (11): 863–6. doi:10.1136/thorax.56.11.863. PMC 1745962. PMID 11641511. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1745962. 
• Köller M, Kutscha-Lissberg F, Brom J, et al. (2003). "Influence of low molecular weight heparin (certoparin) and unfractionated heparin on the release of cytokines from human leukocytes.". Inflammation 25 (5): 331–7. doi:10.1023/A:1012883916991. PMID 11820460. 

External links

• MeSH IL1R1+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.