Interleukin 24

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Interleukin 24
Identifiers
Symbols IL24 ; C49A; FISP; IL10B; MDA7; MOB5; ST16
External IDs OMIM604136 MGI2135548 HomoloGene4991 GeneCards: IL24 Gene
RNA expression pattern
PBB GE IL24 206569 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 11009 93672
Ensembl ENSG00000162892 ENSMUSG00000026420
UniProt Q13007 Q925S4
RefSeq (mRNA) NM_001185156 NM_053095
RefSeq (protein) NP_001172085 NP_444325
Location (UCSC) Chr 1:
207.07 – 207.08 Mb
Chr 1:
130.88 – 130.89 Mb
PubMed search [1] [2]

Interleukin 24 (IL-24) is a protein that in humans is encoded by the IL24 gene.

IL-24 is a cytokine belonging to the IL-10 family of cytokines that signals through two heterodimeric receptors: IL-20R1/IL-20R2 and IL-22R1/IL-20R2. This interleukin is also known as melanoma differentiation-associated 7 (mda-7) due to its discovery as a tumour suppressing protein. IL-24 appears to control in cell survival and proliferation by inducing rapid activation of particular transcription factors called STAT1 and STAT3. This cytokine is predominantly released by activated monocytes, macrophages and T helper 2 (Th2) cells[1] and acts on non-haematopoietic tissues such as skin, lung and reproductive tissues. IL-24 performs important roles in wound healing, psoriasis and cancer.[2] Several studies have shown that cell death occurs in cancer cells/cell lines following exposure to IL-24.[3][4] The gene for IL-24 is located on chromosome 1 in humans.[5]

References[edit]

  1. ^ Poindexter NJ, Walch ET, Chada S, Grimm EA (September 2005). "Cytokine induction of interleukin-24 in human peripheral blood mononuclear cells". J. Leukoc. Biol. 78 (3): 745–52. doi:10.1189/jlb.0205116. PMID 16000394. 
  2. ^ Wang M, Liang P (February 2005). "Interleukin-24 and its receptors". Immunology 114 (2): 166–70. doi:10.1111/j.1365-2567.2005.02094.x. PMC 1782067. PMID 15667561. 
  3. ^ Fisher PB, Gopalkrishnan RV, Chada S, Ramesh R, Grimm EA, Rosenfeld MR, Curiel DT, Dent P (2003). "mda-7/IL-24, a novel cancer selective apoptosis inducing cytokine gene: from the laboratory into the clinic". Cancer Biol. Ther. 2 (4 Suppl 1): S23–37. PMID 14508078. 
  4. ^ Sauane M, Lebedeva IV, Su ZZ, Choo HT, Randolph A, Valerie K, Dent P, Gopalkrishnan RV, Fisher PB (May 2004). "Melanoma differentiation associated gene-7/interleukin-24 promotes tumor cell-specific apoptosis through both secretory and nonsecretory pathways". Cancer Res. 64 (9): 2988–93. doi:10.1158/0008-5472.CAN-04-0200. PMID 15126330. 
  5. ^ IL24 GeneCard

External links[edit]

Interleukin24 bibliography of open articles and PubMed search term