Interleukin 25
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| Interleukin 25 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | IL25; IL-17E; IL-25; IL17E | ||||||||||||
| External IDs | OMIM: 605658 MGI: 2155888 HomoloGene: 15429 GeneCards: IL25 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 64806 | 140806 | |||||||||||
| Ensembl | ENSG00000166090 | ENSMUSG00000040770 | |||||||||||
| UniProt | Q9H293 | Q8VHH8 | |||||||||||
| RefSeq (mRNA) | NM_022789.3 | NM_080729.3 | |||||||||||
| RefSeq (protein) | NP_073626.1 | NP_542767.1 | |||||||||||
| Location (UCSC) | Chr 14: 23.84 – 23.85 Mb |
Chr 14: 55.55 – 55.55 Mb |
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| PubMed search | [1] | [2] | |||||||||||
Interleukin-25 (IL-25) is a protein that in humans is encoded by the IL25 gene.[1][2][3]
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[edit] Function
IL-25 is a cytokine that shares the sequence similarity with IL17. This cytokine can induce NF-κB activation, and stimulate the production of IL8. Both this cytokine and IL17B are ligands for the cytokine receptor IL17RB. Studies of the similar gene in mice suggested that this cytokine may be a proinflammatory cytokine favoring Th2-type immune response. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.[3]
IL-25 is a cytokine that belongs to the IL-17 cytokine family and is secreted by type 2 helper T cells (Th2) and mast cells.[4] It is also known as IL-17E.[5]
[edit] Clinical significance
IL-25 induces the production of other cytokines, including IL-4, IL-5 and IL-13 in multiple tissues, which stimulate the expansion of eosinophils. This cytokine is an important molecule controlling immunity of the gut[6] and has been implicated in chronic inflammation associated with the gastrointestinal tract. IL-25 can kill some types of breast cancer cells.[7]
Further, the IL-25 gene has been identified in a chromosomal region associated with autoimmune diseases of the gut such as inflammatory bowel disease (IBD), although no direct evidence suggests that IL-25 plays any role in this disease.[8]
[edit] References
- ^ Lee J, Ho WH, Maruoka M, Corpuz RT, Baldwin DT, Foster JS, Goddard AD, Yansura DG, Vandlen RL, Wood WI, Gurney AL (Mar 2001). "IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh1". J Biol Chem 276 (2): 1660–4. doi:10.1074/jbc.M008289200. PMID 11058597.
- ^ Fort MM, Cheung J, Yen D, Li J, Zurawski SM, Lo S, Menon S, Clifford T, Hunte B, Lesley R, Muchamuel T, Hurst SD, Zurawski G, Leach MW, Gorman DM, Rennick DM (Dec 2001). "IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo". Immunity 15 (6): 985–95. doi:10.1016/S1074-7613(01)00243-6. PMID 11754819.
- ^ a b "Entrez Gene: IL25 interleukin 25". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64806.
- ^ Ikeda K, Nakajima H, Suzuki K, Kagami S, Hirose K, Suto A, Saito Y, Iwamoto I (May 2003). "Mast cells produce interleukin-25 upon Fc epsilon RI-mediated activation". Blood 101 (9): 3594–6. doi:10.1182/blood-2002-09-2817. PMID 12511410.
- ^ The HGNC site for IL-25
- ^ Owyang AM, Zaph C, Wilson EH, Guild KJ, McClanahan T, Miller HR, Cua DJ, Goldschmidt M, Hunter CA, Kastelein RA, Artis D (April 2006). "Interleukin 25 regulates type 2 cytokine-dependent immunity and limits chronic inflammation in the gastrointestinal tract". J. Exp. Med. 203 (4): 843–9. doi:10.1084/jem.20051496. PMC 1800834. PMID 16606667. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1800834.
- ^ Furuta S, Jeng YM, Zhou L, Huang L, Kuhn I, Bissell MJ, Lee WH (April 2011). "IL-25 Causes Apoptosis of IL-25R-Expressing Breast Cancer Cells Without Toxicity to Nonmalignant Cells". Sci Transl Med 3 (78): 78ra31. doi:10.1126/scitranslmed.3001374. PMC 3199022. PMID 21490275. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3199022. Lay summary – Genetic Engineering & Biotechnology News.
- ^ Büning C, Genschel J, Weltrich R, Lochs H, Schmidt H (October 2003). "The interleukin-25 gene located in the inflammatory bowel disease (IBD) 4 region: no association with inflammatory bowel disease". Eur. J. Immunogenet. 30 (5): 329–33. doi:10.1046/j.1365-2370.2003.00411.x. PMID 14641539.
[edit] Further reading
- Fallon PG, Ballantyne SJ, Mangan NE, Barlow JL, Dasvarma A, Hewett DR, McIlgorm A, Jolin HE, McKenzie AN (April 2006). "Identification of an interleukin (IL)-25-dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion". J. Exp. Med. 203 (4): 1105–16. doi:10.1084/jem.20051615. PMC 2118283. PMID 16606668. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2118283.
- Pan G, French D, Mao W, et al. (2002). "Forced expression of murine IL-17E induces growth retardation, jaundice, a Th2-biased response, and multiorgan inflammation in mice". J. Immunol. 167 (11): 6559–67. PMID 11714825.
- Kim MR, Manoukian R, Yeh R, et al. (2002). "Transgenic overexpression of human IL-17E results in eosinophilia, B-lymphocyte hyperplasia, and altered antibody production". Blood 100 (7): 2330–40. doi:10.1182/blood-2002-01-0012. PMID 12239140.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=403697.
- Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2286551.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Létuvé S, Lajoie-Kadoch S, Audusseau S, et al. (2006). "IL-17E upregulates the expression of proinflammatory cytokines in lung fibroblasts". J. Allergy Clin. Immunol. 117 (3): 590–6. doi:10.1016/j.jaci.2005.10.025. PMID 16522458.
- Tamachi T, Maezawa Y, Ikeda K, et al. (2006). "IL-25 enhances allergic airway inflammation by amplifying a TH2 cell-dependent pathway in mice". J. Allergy Clin. Immunol. 118 (3): 606–14. doi:10.1016/j.jaci.2006.04.051. PMID 16950278.
- Wang YH, Angkasekwinai P, Lu N, et al. (2007). "IL-25 augments type 2 immune responses by enhancing the expansion and functions of TSLP-DC-activated Th2 memory cells". J. Exp. Med. 204 (8): 1837–47. doi:10.1084/jem.20070406. PMC 2118667. PMID 17635955. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2118667.
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