Interleukin 30

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Interleukin 27
Symbols IL27 ; IL-27; IL-27A; IL27A; IL27p28; IL30; p28
External IDs OMIM608273 HomoloGene17087 GeneCards: IL27 Gene
Species Human Mouse
Entrez 246778 246779
Ensembl ENSG00000197272 ENSMUSG00000044701
UniProt Q8NEV9 Q8K3I6
RefSeq (mRNA) NM_145659 NM_145636
RefSeq (protein) NP_663634 NP_663611
Location (UCSC) Chr 16:
28.51 – 28.52 Mb
Chr 7:
126.59 – 126.59 Mb
PubMed search [1] [2]

Interleukin-30 (IL-30) is a protein with a molecular weight of 28 kilodaltons, which forms one chain of the heterodimeric cytokine called interleukin 27 (IL-27), thus is sometimes called IL27-p28. The other chain of IL-27 is a molecule called Epstein-Barr induced gene-3 (EBI3). IL-30 is a member of the long-chain, 4-helix bundle family of cytokines, making it structurally similar to IL-6.[1] This gene for this molecule is now officially called IL-27 under HGNC guidelines.[2]


  1. ^ Pflanz S, Timans JC, Cheung J, Rosales R, Kanzler H, Gilbert J, Hibbert L, Churakova T, Travis M, Vaisberg E, Blumenschein WM, Mattson JD, Wagner JL, To W, Zurawski S, McClanahan TK, Gorman DM, Bazan JF, de Waal Malefyt R, Rennick D, Kastelein RA (June 2002). "IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells". Immunity 16 (6): 779–90. doi:10.1016/S1074-7613(02)00324-2. PMID 12121660. 
  2. ^