Interleukin 32 (IL-32) is a cytokine that can induce cells of the immune system (such as monocytes and macrophages) to secrete tumor necrosis factor-alpha (TNF-α) in addition to chemokines such as IL-8 and MIP-2/CXCL2.[1]
IL-32 can also support osteoclast differentiation but not osteoclast activation by regulating the MAPK/ERK pathway and the actin cytoskeleton. [2]
[edit] References
- ^ Kim SH, Han SY, Azam T, Yoon DY, Dinarello CA. Interleukin-32: a cytokine and inducer of TNFalpha, Immunity, 2005, Volume 22, Issue 1, pages 131-42.
- ^ Mabilleau G and Sabokbar A. Interleukin-32 promotes osteoclast differentiation but not osteoclast activation, PLoS ONE, 2009, Volume 4, Issue 1, pages e4173.
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B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
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