Interleukin 9

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Interleukin 9
Identifiers
Symbols IL9 ; HP40; IL-9; P40
External IDs OMIM146931 MGI96563 HomoloGene492 GeneCards: IL9 Gene
RNA expression pattern
PBB GE IL9 208193 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3578 16198
Ensembl ENSG00000145839 ENSMUSG00000021538
UniProt P15248 P15247
RefSeq (mRNA) NM_000590 NM_008373
RefSeq (protein) NP_000581 NP_032399
Location (UCSC) Chr 5:
135.23 – 135.23 Mb
Chr 13:
56.48 – 56.48 Mb
PubMed search [1] [2]

Interleukin 9, also known as IL-9, is a cytokine (cell signalling molecule) belonging to the group of interleukins.[1]

Function[edit]

The protein encoded by this gene is a cytokine produced by T-cells and specifically by CD4+ helper cells that acts as a regulator of a variety of hematopoietic cells. This cytokine stimulates cell proliferation and prevents apoptosis. It functions through the interleukin-9 receptor (IL9R), which activates different signal transducer and activator (STAT) proteins and thus connects this cytokine to various biological processes. The gene encoding this cytokine has been identified as a candidate gene for asthma. Genetic studies on a mouse model of asthma demonstrated that this cytokine is a determining factor in the pathogenesis of bronchial hyperresponsiveness.[1]

Interleukin-9 has also shown to inhibit melanoma growth in mice.[2]

References[edit]

  1. ^ a b "Entrez Gene: IL9 interleukin 9". 
  2. ^ Purwar R, Schlapbach C, Xiao S, Kang HS, Elyaman W, Jiang X, Jetten AM, Khoury SJ, Fuhlbrigge RC, Kuchroo VK, Clark RA, Kupper TS (July 2012). "Robust tumor immunity to melanoma mediated by interleukin-9-producing T cells". Nat. Med. doi:10.1038/nm.2856. PMC 3518666. PMID 22772464. Lay summarymedicalxpress.com. 

Further reading[edit]