Interstate 164 (I-164) was a spur highway of Interstate 64 between that route and U.S. Highway 41 (US 41) in Evansville, Indiana. I-164, also known as the Robert D. Orr Highway, had a total length of 21.24 miles (34.18 km). Requested as an Interstate and approved in 1968, the freeway was opened to traffic on August 2, 1990.
On November 15, 2013, the Indiana Department of Transportation announced that most of I-164 will be renamed Interstate 69 by the Fall of 2014.
I-164 was signed north–south as it wraps around the east side of the metropolitan area and then east–west as it curved to meet US 41. West of US 41, the freeway became Veterans Memorial Parkway, an urban surface arterial which provides a direct connection with Evansville's central business district. The highway paralleled the Ohio River as it passed around the south side of Evansville. About four miles after Veterans Parkway, I-164 turned north and almost immediately intersected SR 66, locally known as the Lloyd Expressway, which is the another surface arterial through Evansville. After passing SR 64 (Morgan Ave), the route exited Evansville and continued through suburban area. Near the tail north end of the route, SR 57 started a brief concurrency with I-164. I-164 ended soon after at a cloverleaf interchange with I-64. At the time I-164 was built, SR 57 reverted to a two-lane surface highway but in the mid 2000s, I-69 was constructed north of I-64 (which eventually led to the decommissioning of I-164)
A planned extension of I-69 will utilize much of the existing route of I-164 and eventually create a new international trade corridor from Canada to the Rio Grande Valley. The north end of I-164 connects with the new southern Indiana portion of I-69. Most of I-164, from its northern terminus at I-64/I-69 to a point approximately 1.5 miles (2.4 km) east of US 41, will be eventually designated as I-69.