I-180 begins at a diamond interchange with I-80 in Cheyenne, heading north concurrent with I-25 Bus./US 85/US 87 Bus. on four-lane divided North Greeley Highway. South of this interchange, I-25 Bus./US 85/US 87 Bus. continue along North Greeley Highway. From the southern terminus, I-180 passes over Deming Drive and heads near homes and businesses. The road curves northwest and intersects 5th Street at a traffic light. The highway continues along and passes under a pedestrian bridge at 7th Street before crossing 9th Street at a signalized intersection. Past 9th Street, the directions of I-180 split and pass over a large Union Pacific Railroad yard. After this bridge, I-180 reaches its northern terminus at an at-grade signalized intersection with I-80 Bus./US 30. Past this intersection, I-25 Bus./US 85/US 87 Bus. continue north on the one-way pair of Warren Avenue northbound and Central Avenue southbound.
^It isn't clear whether Lincolnway, the road at the northern terminus of I-180 is US 30 or BUS US 30.  There are Business US 30 shields where W Lincolnway splits off from I-80 (Photos: ,  from ) and on E Lincolnway (Photos: ,  from ) but there are East US 30/West US 30 shields at other places, including the I-180 junction.