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Interstate 275 (I-275) may refer to:
- Interstate 275 (Florida), a loop through Tampa, St. Petersburg, and Bradenton in Florida
- Interstate 275 (Michigan), a western bypass of Detroit, Michigan
- Interstate 275 (Ohio–Indiana–Kentucky), a full beltway around Cincinnati, Ohio
- Interstate 275 (Tennessee), a connection to downtown Knoxville, Tennessee, from the north
|This article includes a list of roads, streets, highways, or other routes that are associated with the same title.
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