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Interstate 380 may refer to:
- Interstate 380 (California), a spur from Interstate 280 to U.S. Highway 101 and the San Francisco International Airport
- Interstate 380 (Iowa), a spur from Interstate 80 that starts in Iowa City, Iowa and eventually ends in Waterloo, Iowa
- Interstate 380 (Pennsylvania), a connection between Interstate 80 and Interstate 81 south of Scranton, Pennsylvania
|This disambiguation page lists articles about roads with the same name.
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