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Interstate 380 may refer to:
- I‑380 in California, a spur from Interstate 280 to U.S. Highway 101 and the San Francisco International Airport
- I-380 in Iowa, a spur from Interstate 80 that starts in Iowa City and eventually ends in Waterloo
- I-380 in Pennsylvania, a connection between Interstate 80 and Interstate 81 south of Scranton
|This disambiguation page lists articles about roads with the same name.
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