|Golden Strip Freeway|
|Maintained by SCDOT|
|Length:||42.16 mi (67.85 km)|
|Existed:||1962 – present|
|South end:||I‑26 near Clinton|
| I‑185 near Mauldin
I‑85 near Greenville
|North end:||US 276 in Downtown Greenville|
After exit 42, Interstate 385 turns into a Business Spur and becomes East North Street and later — for northbound motorists only — Beattie Place. The spur promptly ends at US 29 (Church Street) near the Bon Secours Wellness Arena in downtown Greenville.
The explosive economic growth of southern Greenville county is largely attributed to I-385 and its connection to the city of Greenville and the major cities of Atlanta and Charlotte (via I-85). This area is known by locals as the "Golden Strip".
I-385 features a rather unusual rest area in the median strip near Laurens, that serves both directions of traffic. It was completed as part of the original design of the U.S. 276 expressway in 1958, modeled after the type of single median-located rest areas shared by both north and southbound traffic (to save money). The design is similar to many of those built on turnpikes that predated the Interstate System.
|This article needs additional citations for verification. (July 2010)|
The general idea — but none of the specifics — of I-385 were present on the 1955 Yellow Book map of the Greenville area. Also of note is that Interstate 85 would have used the US 29 corridor from Greenville east towards Spartanburg based on the diagram.
The portion of I-385 that replaced US 276 (from SC 417 in Mauldin to SC 56/I-26 in Clinton) was initially the first phase built of an SC DOT plan that predated the Interstate System to upgrade and bypass existing through routes, the goal of forming a single limited-access highway from Greenville to the port of Charleston via the State Capital of Columbia. This plan was scrapped as soon as the future I-26 was added to the act of Congress that set into motion the Interstate System. As a result, I-26 was one of the first Interstates in the south to open in significant mileage (most in SC between 1959 and 1963).
Prior to 1985, I-385 was only signed as such from downtown Greenville to I-85. The portion of the freeway from US 276 in Mauldin to the southern terminus at I-26 was signed as US 276. When the connecting portion was completed, the entire freeway was signed as I-385.
For seven months ending July 23, 2010, northbound traffic could not use a 15-mile section of I-385 in Laurens County due to a $60.9 million project to pave the portion extending from South Carolina Highway 101 to the I-385-I-26 interchange near Clinton, SC in concrete. The closing of a major highway generated controversy. Closing the interstate for construction saved approximately $34 million.
Between 2002 and 2012, I-385 was widened from 2 to 3 lanes in each direction from just north of exit 24 near Fountain Inn to just south of Woodruff Rd/SC 146 (exit 35), with the portion between exits 31 and 35 resurfaced in concrete. 
|Laurens||Clinton||0.00||0.00||I‑26 – Spartanburg, Newberry||Southern terminus|
|2||SC 308 – Ora, Clinton|
|Laurens||5||SC 49 – Laurens, Cross Anchor|
|9||US 221 – Laurens, Enoree|
|Gray Court||10||Metric Road – Gray Court|
|16||SC 101 – Woodruff, Gray Court|
|19||SC 14 east – Owings, Gray Court||South end of SC 14 overlap|
|Fountain Inn||22||SC 14 west – Fountain Inn||North end of SC 14 overlap|
|Greenville||23||SC 418 – Fountain Inn, Pelzer|
|24||Fairview Street – Fountain Inn|
|Simpsonville||26||Harrison Bridge Road|
|27||Fairview Road – Simpsonville|
|29||Georgia Road – Simpsonville|
|Mauldin||30||I‑185 north / US 276 north – Mauldin, Anderson|
|31||SC 417 (Laurens Road) – Mauldin||No southbound exit; southbound exit is via exit 30|
|33||Bridges Road – Mauldin|
|34||Butler Rd. – Mauldin|
|35||SC 146 (Woodruff Rd.) – Mauldin|
|Greenville||36||I‑85 – Spartanburg, Anderson||Signed as exits 36A (north) and 36B (south) northbound
Single exit 36 southbound
|37||Roper Mountain Road|
|40||SC 291 (Pleasantburg Dr.)|
|42||US 276 – Travelers Rest, Mauldin|
|42.16||67.85||East North Street||Northern terminus|
|1.000 mi = 1.609 km; 1.000 km = 0.621 mi
Interstate 385 Business
|Location:||Greenville, South Carolina|
|Length:||0.6 mi (1.0 km)|
Interstate 385 Business (I-385 Bus) was a boulevard grade business spur of I-385 along North Street, between Stone Avenue (US 276) and Church Street (US 29). It also connected US 123 at Academy Street. Sometime between 2007-2012, the route was decommissioned, with no current state/federal maps listing it, nor any physical signage.
- Route Log - Auxiliary Routes of the Eisenhower National System Of Interstate and Defense Highways - Table 2
- American Association of State Highway and Transportation Officials (May 2012). "AASHTO Project Profiles: South Carolina Department of Transportation I-385 Rehabilitation Project". Archived from the original on May 15, 2012. Retrieved May 15, 2012.
- Cay, Nathaniel (2010-07-25). "I-385 reopened after 7-month closure". Greenville News. Retrieved 2010-07-25.
- "I-385 widening". South Carolina Department of Transportation. September 9, 2012. Retrieved January 8, 2013.
- Google Inc. "Business Spur 385". Google Maps (Map). Cartography by Google, Inc. https://maps.google.com/maps?saddr=E+North+St&daddr=E+North+St&hl=en&sll=34.853784,-82.385788&sspn=0.029477,0.055747&geocode=FfXTEwIdwOsW-w%3BFaXKEwId6cEW-w&t=p&mra=dme&mrsp=1&sz=15&z=15. Retrieved May 19, 2013.