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Interstate 395 may refer to:
- Interstate 395 (District of Columbia–Virginia), a spur from I-95 to Washington, D.C.
- Interstate 395 (Connecticut–Massachusetts), a spur from I-95 to Auburn, Massachusetts
- Interstate 395 (Florida), a spur in Miami, Florida
- Interstate 395 (Maine), a spur in Bangor, Maine
- Interstate 395 (Maryland), a spur in Baltimore, Maryland
- Interstate 676, a loop through Philadelphia, Pennsylvania, formerly designated as Interstate 395
|This article includes a list of roads, streets, highways, or other routes that are associated with the same title.
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