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Interstate 680 may refer to:
- I‑680 in California, a connecting freeway between I-80 and I-280 in the San Francisco Bay Area
- I-680 in Nebraska and Iowa, a northern bypass of the Omaha-Council Bluffs area
- I‑680 in Ohio, a loop through Youngstown
- I‑676 in Pennsylvania and New Jersey, designated as Interstate 680 back when I-76 was I-80S
|This disambiguation page lists articles about roads with the same name.
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