By 1914, a pavedcounty road connected Vallejo and Benicia north of the Carquinez Strait, following the present Maine Street, Benicia Road, Columbus Parkway, and K Street. Although state highways were designated to Benicia in 1910 (Legislative Route (LRN) 7, now I-680) and Vallejo in 1931 (LRN 74, now SR 29), this connection was not added until 1935, when LRN 74 (an unsigned designation) was extended east from Vallejo to Benicia and north along former Route 7 to Fairfield. (A short spur connecting Vallejo to the Carquinez Bridge was added to Route 74 in 1937.) LRN 74 initially entered Benicia on K Street and left on East Fifth Street, making several turns in between. Two realignments were built in the 1940s, reducing the number of turns to one, at the corner of L and East Second Streets.
On September 15, 1955, the Bureau of Public Roads approved the Interstate Highway System spurs and connections in urban areas. Among these was a loop around the San Francisco Bay, soon numbered I-280 and I-680. The east half (I-680) incorporated a number of existing legislative routes, including Routes 69, 108, 107, 75, and 74, crossing the Carquinez Strait on the proposed Benicia-Martinez Bridge and ending at I-80 near downtown Vallejo. The first piece of this freeway north of the Carquinez Strait was at the I-80 cloverleaf interchange, built in the late 1950s when I-80 was upgraded through Vallejo. This was an extremely short roadway, beginning at Lemon Street, crossing under I-80 and Laurel Street, and ending at Reis Avenue and Cedar Street. In about 1960, it was extended east to the old highway (Columbus Parkway) between the cities, and was completed to the new bridge in about 1962, the year the bridge opened.
In the 1964 renumbering, the legislative designation of the completed Vallejo-Benicia freeway was changed from Route 74 to Route 680, reflecting its Interstate designation. The short piece of non-freeway in Vallejo, extending west from I-80 to SR 29, became State Route 141. This route followed Benicia Road and Maine Street, the same alignment the state highway had always taken; it initially connected with I-780 via Lemon Street, but later followed Benicia Road from I-80 north of I-780. In 1975, a proposed (and never constructed) extension west and north to SR 37 east of the Napa River was added to Route 141. The route was to be the Waterfront Freeway, scaled down to a boulevard in 1974.
The Federal Highway Administration approved a relocation of I-680 onto the State Route 21 freeway between Benicia and Fairfield in July 1973. To keep the route to Vallejo in the Interstate system, it was renumbered I-780; the corresponding legislative changes were made in 1976. As part of the project to construct a new northbound Benicia-Martinez Bridge, the I-680/I-780 interchange was rebuilt;[when?] the new span opened in August 2007. Route 141 was deleted from the state highway system in 1988, soon after the city of Vallejo constructed Curtola Parkway over (replacing Maryland Street) just to the south, directly connecting I-780 with a surface road to SR 29.
Except where prefixed with a letter, postmiles were measured on the road as it was in 1964, based on the alignment of Route 680 as it existed at that time, and do not necessarily reflect current mileage. R reflects a realignment in the route since then, M indicates a second realignment, L refers an overlap due to a correction or change, and T indicates postmiles classified as temporary (for a full list of prefixes, see the list of postmile definitions). Segments that remain unconstructed or have been relinquished to local control may be omitted. The entire route is in Solano County.
^Grinnon, Edmund (15 May 1914). "Road News from All Over The State". Oakland Tribune. Vallejo to Benicia. paved road; to Napa, paved to county line, rough to one mile beyond city of Napa;|accessdate= requires |url= (help)
^California State Assembly (1935). "An act...relating to State highways". Fifty-first Session of the Legislature. Statutes of California. State of California. Ch. 274 p. 959, 281.: "Route 74 is from a point on Route 8 near the Napa Y to Cordelia via Vallejo and Benicia."
^California State Assembly (1963). "An act...relating to routes on the state highway system". 1963 Session of the Legislature. Statutes of California. State of California. Ch. 385 p. 1182, 1189.: "Route 141 is from Route 80 to Route 29 in Vallejo." "Route 680 is from Route 280 in San Jose to Route 80 in Vallejo passing near Warm Springs, Mission San Jose, Scotts Corners and Sunol, and via Walnut Creek and Benicia."
^California State Assembly (1975). "An act...relating to state bridges and highways...". 1975–1976 Session of the Legislature. Statutes of California. State of California. Ch. 1078 p. 2638.: "Route 141 is the westerly extension of Route 680 from Route 80 to Route 37."