| County |
Location |
Exit |
Destinations |
Notes |
| Old |
New |
| Franklin |
State Line |
Maryland state line. I-81 south continues into Maryland. |
| 1 |
1 |
PA 163 (Mason Dixon Road) |
Interchange straddles Maryland state line. Southbound ramps are in Maryland, and northbound ramps are in Pennsylvania. |
| Antrim Township |
2 |
3 |
US 11 (Molly Pitcher Highway) |
No access from northbound US 11 to southbound I-81 |
| Greencastle |
3 |
5 |
PA 16 – Greencastle, Waynesboro, Mercersburg |
|
| Guilford Township |
4 |
10 |
PA 914 – Marion |
|
| Chambersburg |
5 |
14 |
PA 316 (Wayne Avenue) – Waynesboro |
|
| 6 |
16 |
US 30 (Lincoln Way) – Gettysburg |
|
| 7 |
17 |
Walker Road |
To Norland Avenue and Wilson College |
| Greene Township |
8 |
20 |
PA 997 – Scotland |
Penn State - Mont Alto and Letterkenny Army Depot |
| Southampton Township |
9 |
24 |
PA 696 (Fayette Street) |
|
| Cumberland |
Southampton Township |
10 |
29 |
PA 174 (King Street) – Shippensburg Airport |
|
| Penn Township |
11 |
37 |
PA 233 – Newville |
Park and Ride Lot |
| Carlisle |
12 |
44 |
PA 465 – Plainfield |
Carlisle Fairgrounds. |
| 13 |
45 |
College Street |
Dickinson College, Penn State Dickinson School of Law. |
| 14 |
47 |
PA 34 (Hanover Street) |
U.S. Army War College; split into exits 47A (south) and 47B (north) |
| 15 |
48 |
PA 74 (York Road) |
Northbound exit, southbound entrance |
| 16 |
49 |
PA 641 (High Street) |
Southbound exit, northbound entrance |
| Middlesex Township |
17 |
52 |
  US 11 / I-76 / Penna. Tpk. – New Kingston, Middlesex Township |
Carlisle exit on I-76/PA Turnpike; split into exits 52A (US 11 north) and 52B (I-76 / US 11 south) northbound |
| Silver Spring Township |
18 |
57 |
PA 114 – Mechanicsburg |
|
| Hampden Township |
Southern terminus of I-81/Capital Beltway concurrency. |
| 19 |
59 |
 PA 581 east (Harrisburg Expressway) / US 11 – Camp Hill |
Capital Beltway; south end of concurrency with Captial Beltway |
| 20 |
61 |
PA 944 (Wertzville Road) |
|
| East Pennsboro Township |
21 |
65 |
 US 11 / US 15 – Enola, Marysville |
Central Pennsylvania College; split into exits 65A (south) and 65B (north) |
| Dauphin |
Harrisburg |
22 |
66 |
Front Street — Downtown Harrisburg |
Amtrak Terminal. |
| 23A |
67A |
 US 22 east (Cameron St.) / PA 230 east |
Harrisburg Area Community College. |
| 23B |
67B |
 US 22 west / US 322 west – Lewistown, State College |
South end of concurrency with US 322 |
Southern terminus of I-81/ US 322 concurrency. |
| 24 |
69 |
Progress Avenue |
Widener University. |
| Colonial Park |
Northern terminus of I-81/ US 322 concurrency.
Northern terminus of I-81/Capital Beltway concurrency. |
| 25 |
70 |
 I-83 south / US 322 east – Hershey, York |
Capital Beltway. Harrisburg Airport; north end of concurrency with US 322 / Capital Beltway |
| Paxtonia |
26 |
72 |
US 22 – Paxtonia, Linglestown |
Split into exits 72A (Linglestown) and 72B (Paxtonia to US 22) southbound |
| West Hanover Township |
27 |
77 |
PA 39 – Manada Hill, Hershey |
Hershey Attractions. |
| East Hanover Township |
28 |
80 |
PA 743 – Grantville, Hershey |
|
| Lebanon |
East Hanover Township |
29 |
85 |
PA 934 south – Annville, Fort Indiantown Gap |
Lebanon Valley College; split into exits 85A (south) and 85B (north) northbound |
| Union Township |
N/A |
89 |
I-78 east – Allentown |
Left exit southbound |
| 30 |
90 |
PA 72 – Lebanon |
|
| Schuylkill |
Pine Grove Township |
31 |
100 |
PA 443 – Pine Grove |
|
| Tremont Township |
32 |
104 |
PA 125 – Ravine |
|
| Frailey Township |
33 |
107 |
US 209 – Tremont, Tower City |
|
| 34 |
112 |
PA 25 – Hegins |
|
| Foster Township |
35 |
116 |
PA 901 – Minersville, Mount Carmel |
|
| Butler Township |
35A |
119 |
Highridge Park Road – Hecksherville, Gordon |
|
| Frackville |
36 |
124 |
PA 61 – Saint Clair, Frackville, Pottsville, Shamokin |
Split into exits 124A (south) and 124B (north) |
| Mahanoy Township |
37 |
131 |
PA 54 – Hometown, Mahanoy City, Shenandoah |
Split into exits 131A (east) and 131B (west) |
| Delano Township |
38 |
134 |
Delano |
|
| Kline Township |
39 |
138 |
PA 309 – McAdoo, Tamaqua |
|
| Luzerne |
Hazle Township |
39A |
141 |
 PA 424 / PA 309 – Hazleton |
|
| 40 |
143 |
PA 924 – Hazleton |
|
| Sugarloaf Township |
41 |
145 |
PA 93 – West Hazleton |
Penn State University Hazleton Campus. |
| Butler Township |
N/A |
151 |
I-80 – Bloomsburg, Stroudsburg |
Split into exits 151A (east) and 151B (west) |
| Dorrance |
42 |
155 |
Dorrance |
|
| Nuangola |
43 |
159 |
Nuangola |
|
| Hanover Township |
44 |
164 |
PA 29 north (South Cross Valley Expressway) – Nanticoke |
Luzerne County Community College. |
| Wilkes-Barre |
45 |
165 |
   
 PA 309 south / PA 309 Bus. – Wilkes-Barre, Mountain Top |
Bus. 309 left exit; 309 South right offramp; split into exit 165A (south) and 165B (north); south end of concurrency with PA 309 |
Southern terminus of I-81/ PA 309 concurrency. |
| 46 |
168 |
Highland Park Boulevard — Wilkes-Barre |
Access to Wachovia Arena and Downtown Wilkes-Barre. |
| Plains Township |
Northern terminus of I-81/ PA 309 concurrency. |
| 47 |
170 |
 PA 115 east / PA 309 north (North Cross Valley Expressway) – Bear Creek, Wilkes-Barre, King's College |
Split into exits 170A (PA 115) and 170B (PA 309). |
| Pittstown Township |
48 |
175 |
  PA 315 / I-476 / Penna. Tpk. – Pittston, Dupont |
Wilkes-Barre exit of PA Turnpike Northeast Extension. |
| Avoca |
49 |
178 |
 PA 315 – Avoca, Wilkes-Barre/Scranton International Airport |
|
| Lackawanna |
Moosic |
50 |
180 |
 US 11 / PA 502 – Moosic |
No access from southbound I-81 to northbound US 11 |
| Scranton |
51 |
182 |
Montage Mountain Road, Davis Street |
Access to PNC Field and Snö Mountain ski area |
| 52A |
184 |
 
PA 307 (River St.) |
Northbound exit, southbound entrance |
| 52B |
184 |
PA 307 (Moosic St.) |
Southbound exit, northbound entrance |
| 53 |
185 |
Central Scranton Expressway |
Access to Scranton Memorial Stadium and University of Scranton. |
| Dunmore |
54 |
186 |
Drinker Street |
Northbound exit, southbound entrance |
| N/A |
187 |
  I-84 east to I-380 south / US 6 east – Milford, Mount Pocono, Carbondale |
Throop Dunmore Interchange; south end of concurrency with US 6 |
Southern terminus of I-81/ US 6 concurrency. |
| 55 |
188 |
PA 347 – Throop, Dunmore |
Access to Penn State- Worthington Scranton Campus and Marywood University. |
| Scranton |
56 |
190 |
Main Avenue – Dickson City |
|
| 57 |
191 |
 
 US 6 Bus. / US 11 (North Scranton Expressway) – Dickson City, North Scranton |
Split into exits 191A (US 6 Bus.) and 191B (US 11) |
| South Abington Township |
Northern terminus of I-81/ US 6 concurrency. |
| 58 |
194 |
   US 6 west / US 11 south / I-476 / Penna. Tpk. – Clarks Summit |
Clarks Summit exit of PA Turnpike Northeast Extension. Northern terminus of Northeast Extension; north end of concurrency with US 6 |
| Scott Township |
59 |
197 |
PA 632 – Waverly |
|
| 60 |
199 |
PA 524 – Scott Township |
|
| 61 |
201 |
PA 438 – East Benton |
|
| Benton Township |
62 |
202 |
PA 107 – Fleetville, Tompkinsville |
|
| Susquehanna |
Lenox Township |
63 |
206 |
PA 374 – Glenwood, Lenoxville |
|
| 64A |
211 |
PA 106 – Lenox |
Northbound exit, southbound entrance |
| 64B |
211 |
PA 92 – Lenox |
Southbound exit, northbound entrance |
| Harford Township |
65 |
217 |
PA 547 – Harford |
|
| New Milford Township |
66 |
219 |
PA 848 – Gibson |
|
| New Milford |
67 |
223 |
PA 492 – New Milford, Lakeside |
|
| Hallstead |
68 |
230 |
PA 171 – Great Bend, Susquehanna |
Last exit in Pennsylvania. |
New York state line. I-81 north continues into New York. |