Intra-aortic balloon pump
The Intra-aortic balloon pump (IABP) is a mechanical device that increases myocardial oxygen perfusion while at the same time increasing cardiac output. Increasing cardiac output increases coronary blood flow and therefore myocardial oxygen delivery. It consists of a cylindrical polyethylene balloon that sits in the aorta, approximately 2 centimeters (0.79 in) from the left subclavian artery and counterpulsates. That is, it actively deflates in systole, increasing forward blood flow by reducing afterload through a vacuum effect. It actively inflates in diastole, increasing blood flow to the coronary arteries via retrograde flow. These actions combine to decrease myocardial oxygen demand and increase myocardial oxygen supply.  
A computer-controlled mechanism inflates the balloon with helium from a cylinder during diastole, usually linked to either an electrocardiogram (ECG) or a pressure transducer at the distal tip of the catheter; some IABPs, such as the Datascope System 98XT, allow asynchronous counterpulsation at a set rate, though this setting is rarely used. Helium is used because its low viscosity allows it to travel quickly through the long connecting tubes, and has a lower risk than air of causing an embolism should the balloon rupture.
- Cardiogenic shock when used alone as treatment for myocardial infarction. 9-22% survive the first year.
- Reversible intracardial mechanical defects complicating infarction, i.e. acute mitral regurgitation and septal perforation.
- Unstable angina pectoris benefits from counterpulsation.
- Post cardiothoracic surgery—most common and useful is counterpulsation in weaning patients from cardiopulmonary bypass after continued perioperative injury to myocardial tissue.
- Preoperative use is suggested for high-risk patients such as those with unstable angina with stenosis greater than 70% of main coronary artery, in ventricular dysfunction with an ejection fraction less than 35%.
- Percutaneous coronary angioplasty
- In high risk coronary artery bypass graft surgery where cardiopulmonary bypass time was shortened, as well as during intubation period and hospital stay.
- Thrombolytic therapy of acute myocardial infarction.
The following conditions make IABP therapy inadvisable except under pressing circumstances:
Since the device is placed in the femoral artery and aorta it could provoke ischemia, and compartment syndrome. The leg is at highest risk of becoming ischemic if the femoral artery it is supplied by becomes obstructed. Placing the balloon too distal from the arcus aortae may induce occlusion of the renal artery and subsequent renal failure. Other possible complications are cerebral embolism during insertion, infection, dissection of the aorta or iliac artery, perforation of the artery and hemorrhage in the mediastinum. Mechanical failure of the balloon itself is also a risk which entails vascular surgery to remove under that circumstance. After balloon removal there is also a risk of 'embolic shower' from micro clots that have formed on the surface of the balloon, and can lead to peripheral thrombosis, myocardial ischemia, hemodynamic decompensation, and late pseudoaneurysm.  
The first publication of intra-aortic balloon counter-pulsation appeared in the American Heart Journal of May 1962; 63: 669-675 by S. Moulopoulos, S. Topaz and W. Kolff.
The device and the balloons were then developed for commercial use between 1967 and 1969 heart surgery by William Rassman, M.D. at Cornell Medical Center and were manufactured by Datascope Corporation in 1969. The system was subsequently used clinically by Dr. David Bregman in 1976 at NewYork-Presbyterian Hospital in New York City.
The first clinical implant was performed at Maimonides Medical Center, Brooklyn, N.Y. in Oct., 1967. The patient, a 48 year old woman, was in cardiogenic shock and unresponsive to traditional therapy. An IABP was inserted by a cut down on the left femoral artery. Pumping was performed for approximately 6 hours. Shock reversed and the patient was discharged.
The size of the original balloon was 15 French but eventually 9 and 8 French balloons were developed. A second operation removed the balloon. Since 1979 the placement of the balloon has been modified using the Seldinger technique.
- "Intra-aortic Balloon Pump". Texas Heart Institute.
- Intensive Care Medicine by Irwin and Rippe
- Intra Aortic Balloon Pump (IABP) Counterpulsation mirror with better quality by P. J Overwalder, M.D., Department of Surgery, Division of Cardiac Surgery, University Hospital Graz, The Internet Journal of Thoracic and Cardiovascular Surgery. 1999. Volume 2 Number 2.
- Intra-aortic balloon pumping Department of Anaesthesia and Intensive Care of The Chinese University of Hong Kong
- Usage of Intra-Aortic Balloon Pump in High Risk Coronary Artery Bypass Graft Surgery by K. Jai Shankar
- http://www.rjmatthewsmd.com/Definitions/IABP_Counterpulsation.htm Intra Aortic Balloon Pump (IABP) Counterpulsation by P. J Overwalder, M.D.
- "NewYork-Presbyterian Heart 'Firsts'", available at http://www.nyp.org/about/heart-firsts.html
- Kantrowitz, A., Tjonneland, S., Freed, P.S., Phillips, S.J., Butner, A.N., Sherman, J.L., Jr.: Initial clinical experience with intra-aortic balloon pumping in cardiogenic shock. JAMA, 1968; 203(2):113-8
- Intra-italheartj.org/pdf_files/20050080.pdf Images in cardiovascular medicine The missing intra-aortic balloon pump catheter by Pasquale Totaro, Nello Degno, John Smith, Vincenzo Argano, Cardiac Surgery Department, Regional Cardiac Center, Morriston Hospital, Swansea, UK, Ital Heart J 2005; 6 (4): 361-362)