Intravascular large B-cell lymphoma

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Intravascular large B-cell lymphoma
Classification and external resources
Intravascular lymphoma - very high mag.jpg
Micrograph showing an intravascular large B-cell lymphoma in a blood vessel of the brain. H&E stain.
ICD-O: 9712/3

Intravascular large B-cell lymphoma, abbreviated ILBCL and also referred to as angiotropic large-cell lymphoma,[1] intralymphatic lymphomatosis,[2] intravascular lymphomatosis,[2] and, less specifically, intravascular lymphoma.[3][4]

Diagnosis[edit]

ILBCL is a condition that may present with non-specific symptoms and, thus, may be difficult to diagnose in a timely manner.[5]

Presentations may include non-specific cutaneous lesions,[1]:742 and/or CNS involvement.[6]

The diagnosis is established by the examination of tissue under the microscope (i.e. biopsy or autopsy) and immunohistochemical stains.

History[edit]

It used to be known as malignant angioendotheliomatosis, as it was once thought to arise from the endothelium.[7]

See also[edit]

References[edit]

  1. ^ a b James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0. 
  2. ^ a b Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 1-4160-2999-0. 
  3. ^ Wang L, Li C, Gao T (March 2010). "Cutaneous intravascular anaplastic large cell lymphoma". J Cutan Pathol 38 (2): 221–226. doi:10.1111/j.1600-0560.2010.01538.x. PMID 20337769. 
  4. ^ Lee BS, Frankfort BJ, Eberhart CG, Weinberg RS (October 2010). "Diagnosis of Intravascular Lymphoma by a Novel Biopsy Site". Ophthalmology 118 (3): 586–590. doi:10.1016/j.ophtha.2010.08.001. PMID 21035865. 
  5. ^ Ferry JA (April 2008). "Extranodal lymphoma". Arch. Pathol. Lab. Med. 132 (4): 565–78. doi:10.1043/1543-2165(2008)132[565:EL]2.0.CO;2. PMID 18384208. 
  6. ^ Lapkuviene O, Forchetti D, Roepke JE (October 2001). "Unusual sites of involvement by hematologic malignancies. Case 1. Intravascular large B-cell lymphoma presenting with CNS symptoms". J. Clin. Oncol. 19 (19): 3988–91. PMID 11579120. 
  7. ^ Sheibani K, Battifora H, Winberg CD, et al. (April 1986). "Further evidence that "malignant angioendotheliomatosis" is an angiotropic large-cell lymphoma". N. Engl. J. Med. 314 (15): 943–8. doi:10.1056/NEJM198604103141502. PMID 3485768.