Intravascular large B-cell lymphoma

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Intravascular large B-cell lymphoma
Classification and external resources
Intravascular lymphoma - very high mag.jpg
Micrograph showing an intravascular large B-cell lymphoma in a blood vessel of the brain. H&E stain.
ICD-O: 9712/3

Intravascular large B-cell lymphoma, abbreviated ILBCL and also referred to as angiotropic large-cell lymphoma,[1] intralymphatic lymphomatosis,[2] intravascular lymphomatosis,[2] and, less specifically, intravascular lymphoma.[3][4]


ILBCL is a condition that may present with non-specific symptoms and, thus, may be difficult to diagnose in a timely manner.[5]

Presentations may include non-specific cutaneous lesions,[1]:742 and/or CNS involvement.[6]

The diagnosis is established by the examination of tissue under the microscope (i.e. biopsy or autopsy) and immunohistochemical stains.


It used to be known as malignant angioendotheliomatosis, as it was once thought to arise from the endothelium.[7]

See also[edit]


  1. ^ a b James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0. 
  2. ^ a b Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 1-4160-2999-0. 
  3. ^ Wang L, Li C, Gao T (March 2010). "Cutaneous intravascular anaplastic large cell lymphoma". J Cutan Pathol 38 (2): 221–226. doi:10.1111/j.1600-0560.2010.01538.x. PMID 20337769. 
  4. ^ Lee BS, Frankfort BJ, Eberhart CG, Weinberg RS (October 2010). "Diagnosis of Intravascular Lymphoma by a Novel Biopsy Site". Ophthalmology 118 (3): 586–590. doi:10.1016/j.ophtha.2010.08.001. PMID 21035865. 
  5. ^ Ferry JA (April 2008). "Extranodal lymphoma". Arch. Pathol. Lab. Med. 132 (4): 565–78. doi:10.1043/1543-2165(2008)132[565:EL]2.0.CO;2. PMID 18384208. 
  6. ^ Lapkuviene O, Forchetti D, Roepke JE (October 2001). "Unusual sites of involvement by hematologic malignancies. Case 1. Intravascular large B-cell lymphoma presenting with CNS symptoms". J. Clin. Oncol. 19 (19): 3988–91. PMID 11579120. 
  7. ^ Sheibani K, Battifora H, Winberg CD, et al. (April 1986). "Further evidence that "malignant angioendotheliomatosis" is an angiotropic large-cell lymphoma". N. Engl. J. Med. 314 (15): 943–8. doi:10.1056/NEJM198604103141502. PMID 3485768.