Intraventricular hemorrhage

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Intraventricular hemorrhage
Classification and external resources
Intracerebral hemorrhage.jpg
CT scan showing spontaneous intracerebral hemorrhage with bleeding in the third and both lateral ventricles and hydrocephalus[1]
ICD-10 I61.5, P10.2, P52
ICD-9 431, 772.1
DiseasesDB 6906
eMedicine ped/2595
MeSH D002543

An intraventricular hemorrhage (or intraventricular haemorrhage in British English), often abbreviated "IVH," is a bleeding into the brain's ventricular system, where the cerebrospinal fluid is produced and circulates through towards the subarachnoid space. It can result from physical trauma or from hemorrhaging in stroke.

In infants[edit]

This type of hemorrhage is particularly common in infants, especially premature infants or those of very low birth weight.[2] The cause of IVH in premature infants, unlike that in older infants, children or adults, is rarely due to trauma. Instead it is thought to result from changes in perfusion of the delicate cellular structures that are present in the growing brain, augmented by the immaturity of the cerebral circulatory system, which is especially vulnerable to hypoxic ischemic encephalopathy. The lack of blood flow results in cell death and subsequent breakdown of the blood vessel walls, leading to bleeding. While this bleeding can result in further injury, it is itself a marker for injury that has already occurred. Most intraventricular hemorrhages occur in the first 72 hours after birth.[2] The risk is increased with use of extracorporeal membrane oxygenation in preterm infants.[3]

The amount of bleeding varies. IVH is often described in four grades:

  • Grade I - bleeding occurs just in the germinal matrix
  • Grade II - bleeding also occurs inside the ventricles, but they are not enlarged
  • Grade III - ventricles are enlarged by the accumulated blood
  • Grade IV - bleeding extends into the brain tissue around the ventricles

Grades I and II are most common, and often there are no further complications. Grades III and IV are the most serious and may result in long-term brain injury to the infant. After a grade III or IV IVH, blood clots may form which can block the flow of cerebrospinal fluid, leading to increased fluid in the brain (hydrocephalus).

There have been various therapies employed into preventing the high rates of morbidity and mortality, including diuretic therapy,[4] repeated lumbar puncture,[5] streptokinase therapy [6] and most recently combination a novel intervention called DRIFT (drainage, irrigation and fibrinolytic therapy).

In 2002, a Dutch retrospective study[7] analysed cases where neonatologists had intervened and drained CSF by lumbar or ventricular punctures if ventricular width (as shown on ultrasound) exceeded the 97th centile as opposed to the 97th centile plus 4 mm.[8] Professors Whitelaw's original cochrane [4] review published in 2001 as well as evidence from previous randomised control trials indicated that interventions should be based on clinical signs and symptoms of ventricular dilatation. An international trial has instead looked an early (97th centile) versus late (97th centile plus 4 mm) for intervening and draining CSF.[9]

DRIFT has been tested in an international randomised clinical trial; although it did not significantly lower the need for shunt surgery, severe cognitive disability at two years Bayley (MDI <55) was significantly reduced.[10] Repeated lumbar punctures are used widely to reduce the effects in increased intracranial pressure and an alternative to ventriculo-shunt (VP) surgery that cannot be performed in case of intraventricular haemorrhage. The relative risk of repeated lumbar puncture is close to 1.0, therefore it is not statistically therapeutic when compared to conservative management and does raise the risk of subsequent CSF infection.[5] Another DRIFT trial is planned[when?] involving a large number of infants to validate previous data and expand on the viability of performing the invasive procedure nationwide.

In adults[edit]

Intraventricular hemorrhage has been found to occur in 35% of moderate to severe traumatic brain injuries.[11] The injury requires a great deal of force to cause. Thus the hemorrhage usually does not occur without extensive associated damage, and so the outcome is rarely good.[12][13]

Prognosis is also very poor when IVH results from intracerebral hemorrhage related to high blood pressure and is even worse when hydrocephalus follows.[1] It can result in dangerous increases in intracranial pressure and can cause potentially fatal brain herniation.[1]

Associated conditions[edit]

Brain contusions and subarachnoid hemorrhages are commonly associated with IVH.[14] The bleeding can involve the middle communicating artery or the posterior communicating artery.

In both adults and infants, IVH can cause dangerous increases in intracranial pressure, damage to the brain tissue, and hydrocephalus.[2][15]

References[edit]

  1. ^ a b c Yadav, Yad; Mukerji, Gaurav; Shenoy, Ravikiran; Basoor, Abhijeet; Jain, Gaurav; Nelson, Adam (2007). "Endoscopic management of hypertensive intraventricular haemorrhage with obstructive hydrocephalus". BMC Neurology 7: 1. doi:10.1186/1471-2377-7-1. PMC 1780056. PMID 17204141. 
  2. ^ a b c Annibale DJ and Hill J. 2006. Periventricular Hemorrhage-Intraventricular Hemorrhage. Emedicine.com. Retrieved on June 19, 2007.
  3. ^ Jobe, Alan H. (2004). "Post-conceptional age and IVH in ECMO patients". The Journal of Pediatrics 145 (2): A2. doi:10.1016/j.jpeds.2004.07.010. 
  4. ^ a b Whitelaw, Andrew; Brion, Luc P; Kennedy, Colin R; Odd, David (2001). "Diuretic therapy for newborn infants with posthemorrhagic ventricular dilatation". In Whitelaw, Andrew. Cochrane Database of Systematic Reviews. doi:10.1002/14651858.CD002270. 
  5. ^ a b Whitelaw, Andrew (2001). "Repeated lumbar or ventricular punctures in newborns with intraventricular hemorrhage". In Whitelaw, Andrew. Cochrane Database of Systematic Reviews. doi:10.1002/14651858.CD000216. 
  6. ^ Whitelaw, Andrew; Odd, David; Brion, Luc P; Kennedy, C R (2007). "Intraventricular streptokinase after intraventricular hemorrhage in newborn infants". In Whitelaw, Andrew. Cochrane Database of Systematic Reviews. doi:10.1002/14651858.CD000498.pub2. 
  7. ^ de Vries, LS; Liem, KD; Van Dijk, K; Smit, BJ; Sie, L; Rademaker, KJ; Gavilanes, AWD; Dutch Working Group of Neonatal Neurology (2007). "Early versus late treatment of post-haemorrhagic ventricular dilatation: Results of a retrospective study from five neonatal intensive care units in the Netherlands". Acta Paediatrica 91 (2): 212–7. doi:10.1111/j.1651-2227.2002.tb01697.x. PMID 11952011. 
  8. ^ Volpe, Joseph J. (1989). "Intraventricular hemorrhage in the premature infant?current concepts. Part I". Annals of Neurology 25 (1): 3–11. doi:10.1002/ana.410250103. PMID 2913926. 
  9. ^ http://www.bris.ac.uk/clinicalsciencenorth/neonatal/ri/phitt.html
  10. ^ Whitelaw, A.; Jary, S.; Kmita, G.; Wroblewska, J.; Musialik-Swietlinska, E.; Mandera, M.; Hunt, L.; Carter, M.; Pople, I. (2010). "Randomized Trial of Drainage, Irrigation and Fibrinolytic Therapy for Premature Infants with Posthemorrhagic Ventricular Dilatation: Developmental Outcome at 2 years". Pediatrics 125 (4): e852–8. doi:10.1542/peds.2009-1960. PMID 20211949. 
  11. ^ Barkley JM, Morales D, Hayman LA, Diaz-Marchan PJ (2006). "Static neuroimaging in the evaluation of TBI". In Zasler ND, Katz DI, Zafonte RD. Brain Injury Medicine: Principles and Practice. Demos Medical Publishing. pp. 140–43. ISBN 1-888799-93-5. 
  12. ^ Dawodu S. 2007. "Traumatic Brain Injury: Definition, Epidemiology, Pathophysiology" Emedicine.com. Retrieved on June 19, 2007.
  13. ^ Vinas FC and Pilitsis J. 2006. "Penetrating Head Trauma." Emedicine.com.
  14. ^ Leroux, Peter D.; Haglund, Michael M.; Newell, David W.; Grady, M. Sean; Winn, H. Richard (1992). "Intraventricular Hemorrhage in Blunt Head Trauma". Neurosurgery 31 (4): 678–84; discussion 684–5. doi:10.1227/00006123-199210000-00010. PMID 1407453. 
  15. ^ Mayfrank, L.; Kissler, J.; Raoofi, R.; Delsing, P.; Weis, J.; Küker, W.; Gilsbach, J.M.; Muizelaar, J. P. (1997). "Ventricular Dilatation in Experimental Intraventricular Hemorrhage in Pigs: Characterization of Cerebrospinal Fluid Dynamics and the Effects of Fibrinolytic Treatment". Stroke 28 (1): 141–8. doi:10.1161/01.STR.28.1.141. PMID 8996503. 

External links[edit]