Invasive lobular carcinoma
Classification and external resources
Invasive lobular carcinoma demonstrating a predominantly lobular growth pattern
Lobular breast cancer. Single file cells and cell nests.
Invasive lobular carcinoma accounts for 5-10% of invasive breast cancer. [1 ] [2 ]
The histologic patterns include:
[3 ] [4 ] [5 ]
round or ovoid cells with little cytoplasm in a single-file infiltrating pattern, sometimes concentrically giving a
Aggregates of classical-appearing cells
Sheets of classical-appearing cells with little intervening
Cells form microtubules in >90% of tumor (smaller than in tubular carcinoma)
Classical-appearing but with
No dominant pattern
Overall, the five-year survival rate of invasive lobular carcinoma was approximately 85% in 2003.
E-cadherin is common in lobular carcinoma but is also seen in other breast cancers. [7 ]
Treatment includes surgery and adjuvant therapy.
References [ edit ]
^ Pointon KS, Cunningham DA (August 1999). "Ultrasound findings in pure invasive lobular carcinoma of the breast: comparison with matched cases of invasive ductal carcinoma of the breast". Breast 8 (4): 188–90. doi: 10.1054/brst.1999.0042. PMID 14731438.
^ Boughey JC, Wagner J, Garrett BJ, et al (March 2009). "Neoadjuvant Chemotherapy in Invasive Lobular Carcinoma May Not Improve Rates of Breast Conservation". Ann. Surg. Oncol. 16 (6): 1606–11. doi: 10.1245/s10434-009-0402-z. PMID 19280264.
^ Moore MM, Borossa G, Imbrie JZ, et al (June 2000). "Association of Infiltrating Lobular Carcinoma With Positive Surgical Margins After Breast-Conservation Therapy". Ann. Surg. 231 (6): 877–82. doi: 10.1097/00000658-200006000-00012. PMC 1421077. PMID 10816631.
^ Spencer JT, Shutter J (March 2009). "Synchronous bilateral invasive lobular breast cancer presenting as carcinomatosis in a male". Am. J. Surg. Pathol. 33 (3): 470–4. doi: 10.1097/PAS.0b013e318190d10d. PMID 19092630.
^ Fletcher's diagnostic histopathology of tumors. 3rd Ed. p. 931-932.
^ Arpino G, Bardou VJ, Clark GM, Elledge RM (2004). "Infiltrating lobular carcinoma of the breast: tumor characteristics and clinical outcome". Breast Cancer Res. 6 (3): R149–56. doi: 10.1186/bcr767. PMC 400666. PMID 15084238.
^ Varga Z, Mallon E. (Oct 2009). "Histology and Immunophenotype of Invasive Lobular Breast Cancer. Daily Practice and Pitfalls". Breast Dis. 30: 15–19. doi: 10.3233/BD-2009-0278. PMID 19850991.