Iodotyrosine deiodinase

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Iodotyrosine deiodinase
Identifiers
EC number 1.22.1.1
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Iodotyrosine deiodinase
Identifiers
Symbols IYD ; C6orf71; DEHAL1; TDH4; dJ422F24.1
External IDs OMIM612025 MGI1917587 HomoloGene12352 GeneCards: IYD Gene
EC number 1.22.1.1
Orthologs
Species Human Mouse
Entrez 389434 70337
Ensembl ENSG00000009765 ENSMUSG00000019762
UniProt Q6PHW0 Q9DCX8
RefSeq (mRNA) NM_001164694 NM_027391
RefSeq (protein) NP_001158166 NP_081667
Location (UCSC) Chr 6:
150.69 – 150.73 Mb
Chr 10:
3.54 – 3.55 Mb
PubMed search [1] [2]

Iodotyrosine deiodinase also known as iodotyrosine dehalogenase 1 is an enzyme that in humans is encoded by the IYD gene.[1][2][3] It helps scavenge iodine by removing it from iodinated tyrosines, after these are produced when thyroid hormones that have been broken down as metabolites from their double-tyrosine residue structure.

Unlike the other deiodinases (the iodothyronine deiodinases), that remove iodine only from iodinated thyroid hormones while these are still in their double-tyrosine residue form, the iodotyrosine deiodinases remove iodine from iodinated tyrosine as a single amino acid residue. Also, unlike the iodothyronine deiodinases, the tyrosine deiodinase does not use selenium in the active site.

Function[edit]

Iodotyrosine deiodinase facilitates iodide salvage in thyroid by catalyzing deiodination of mono- and diiodotyrosine, the halogenated byproducts of thyroid hormone production.[2]

Clinical significance[edit]

Mutations in the IYD gene are associated with hypothyroidism.[4]

See also[edit]

References[edit]

  1. ^ Gnidehou S, Caillou B, Talbot M, Ohayon R, Kaniewski J, Noël-Hudson MS, Morand S, Agnangji D, Sezan A, Courtin F, Virion A, Dupuy C (October 2004). "Iodotyrosine dehalogenase 1 (DEHAL1) is a transmembrane protein involved in the recycling of iodide close to the thyroglobulin iodination site". FASEB J. 18 (13): 1574–6. doi:10.1096/fj.04-2023fje. PMID 15289438. 
  2. ^ a b Friedman JE, Watson JA, Lam DW, Rokita SE (February 2006). "Iodotyrosine deiodinase is the first mammalian member of the NADH oxidase/flavin reductase superfamily". J. Biol. Chem. 281 (5): 2812–9. doi:10.1074/jbc.M510365200. PMID 16316988. 
  3. ^ "Entrez Gene: IYD Iodotyrosine deiodinase". 
  4. ^ Moreno JC, Klootwijk W, van Toor H, Pinto G, D'Alessandro M, Lèger A, Goudie D, Polak M, Grüters A, Visser TJ (April 2008). "Mutations in the iodotyrosine deiodinase gene and hypothyroidism". N. Engl. J. Med. 358 (17): 1811–8. doi:10.1056/NEJMoa0706819. PMID 18434651. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.