Iofetamine (123I)

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Iofetamine (123I)
Iofetamine.svg
Systematic (IUPAC) name
1-[4-(123I)iodophenyl]-N-isopropyl-2-propanamine
Clinical data
Legal status
  • Prescription only
Pharmacokinetic data
Protein binding <10%
Identifiers
CAS number 75917-92-9
85068-76-4 (non-labeled)
95896-48-3 (123I-labeled HCl)
ATC code V09AB01
PubChem CID 156375
ChemSpider 137706
ChEMBL CHEMBL1201308
Chemical data
Formula C12H18123IN
Mol. mass 299.278 g/mol

Iofetamine (123I) (INN; brand names Perfusamine, SPECTamine), or N-isopropyl-(123I)-p-iodoamphetamine (IMP), is a lipid-soluble amine and radiopharmaceutical drug used in cerebral blood perfusion imaging with single photon emission computed tomography (SPECT).[1][2][3] Labeled with the radioactive isotope iodine-123, it is approved for use in the United States as a diagnostic aid in determining the localization of and in the evaluation of non-lacunar stroke and complex partial seizures, as well as in the early diagnosis of Alzheimer's disease.[1][2]

An analogue of amphetamine, iofetamine has shown to inhibit the reuptake of serotonin and norepinephrine as well as induce the release of these neurotransmitters and of dopamine with similar potencies to other amphetamines like d-amphetamine and p-chloroamphetamine.[4][5] In addition, on account of its high lipophilicity, iofetamine rapidly penetrates the blood-brain-barrier.[6] Accordingly, though not known to have been reported in the medical literature, iofetamine likely possesses psychostimulant and possibly entactogenic effects.[citation needed] However, based on structure-activity relationships, it may also be highly neurotoxic to serotonergic and dopaminergic neurons similarly to most other para-halogenated amphetamines.[citation needed]

See also[edit]

References[edit]

  1. ^ a b Index Nominum 2000: International Drug Directory. Taylor & Francis US. 2000. p. 562. ISBN 978-3-88763-075-1. Retrieved 25 April 2012. 
  2. ^ a b Druckenbrod RW, Williams CC, Gelfand MJ (January 1989). "Iofetamine hydrochloride I 123: a new radiopharmaceutical for cerebral perfusion imaging". DICP : the Annals of Pharmacotherapy 23 (1): 19–24. PMID 2655294. 
  3. ^ Holman BL, Hill TC, Magistretti PL (1982). "Brain imaging with emission computed tomography and radiolabeled amines". Investigative Radiology 17 (3): 206–15. doi:10.1097/00004424-198201730-00002. PMID 6811496. 
  4. ^ Winchell HS, Horst WD, Braun L, Oldendorf WH, Hattner R, Parker H (October 1980). "N-isopropyl-[123I] p-iodoamphetamine: single-pass brain uptake and washout; binding to brain synaptosomes; and localization in dog and monkey brain". Journal of Nuclear Medicine 21 (10): 947–52. PMID 6775056. 
  5. ^ de Jong BM, Feenstra MG, Ruijter JM, van Royen EA (March 1989). "Serotonin uptake in cerebral cortex cultures: imipramine-like inhibition by N-isopropyl-p-iodoamphetamine". Experimental Neurology 103 (3): 297–9. doi:10.1016/0014-4886(89)90055-1. PMID 2920796. 
  6. ^ Winchell HS, Baldwin RM, Lin TH (October 1980). "Development of I-123-labeled amines for brain studies: localization of I-123 iodophenylalkyl amines in rat brain". Journal of Nuclear Medicine 21 (10): 940–6. PMID 7420195.