Ionomycin

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Ionomycin
Ionomycin free acid.png
Names
IUPAC name
(4R,​6S,​8S,​10Z,​12R,​14R,​16E,​18R,​19R,​20S,​21S)-​19,​21-​dihydroxy-​22-​{(2S,​2'R,​5S,​5'S)-​5'-​[(1R)-​1-​hydroxyethyl]-​2,​5'-​dimethyloctahydro-​2,​2'-​bifuran-​5-​yl}-​4,​6,​8,​12,​14,​18,​20-​heptamethyl-​11-​oxido-​9-​oxodocosa-​10,​16-​dienoic acid
Identifiers
56092-81-0 YesY
ChEMBL ChEMBL501617 N
ChEMBL1222121 N
ChemSpider 5288579 N
Jmol-3D images Image
PubChem 6912226
Properties
C41H72O9
Molar mass 709.00 g·mol−1
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N verify (what isYesY/N?)
Infobox references

Ionomycin is an ionophore produced by the bacterium Streptomyces conglobatus.[1] It is used in research to raise the intracellular level of calcium (Ca2+) and as a research tool to understand Ca2+ transport across biological membranes. It is also used to stimulate the intracellular production of the following cytokines; interferon, perforin, IL-2, and IL-4 - usually in conjunction with PMA. These cytokines are important in the inflammatory response.

Commercially, Ionomycin can be obtained as a free acid, or as a Ca2+ salt.

References[edit]

  1. ^ See Ionomycin Calcium salt from Fermentek, manufacturer's product page for ionomycin