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Carrier ionophores

An ionophore is a lipid-soluble molecule that transports ions across a cell membrane. Ionophores are important because the interior of the lipid bilayer of the membrane is hydrophobic, so ions cannot pass through easily because they are charged.

Ionophores are usually synthesized by microorganisms to import ions into their cells.

The two broad classifications of ionophores are:

  1. Carrier ionophores that bind to a particular ion and shield its charge from the surrounding environment. This makes it easier for the ion to pass through the hydrophobic interior of the lipid membrane.[1] An example of a carrier ionophore is valinomycin, a molecule that transports a single potassium cation. Carrier ionophores may be proteins or other molecules.
  2. Channel formers that introduce a hydrophilic pore into the membrane, allowing ions to pass through without coming into contact with the membrane's hydrophobic interior.[2] An example of a channel former is gramicidin A. Channel forming ionophores are usually large proteins.

Mechanism of action[edit]

The structure of the complex of sodium (Na+) and the antibiotic monensin A

Transmembrane ion concentration gradients (membrane potential) is required for the proper functioning and survival of microorganisms. Ionophores disrupt the membrane potential by conducting ions through a lipid membrane in the absence of a protein pore, and thus could exhibit cytotoxic properties. They are produced naturally by a variety of microbes and act as a defense against competing microbes. Many antibiotics, particularly the macrolide antibiotics, are ionophores that exhibit high affinities for Na+ or K+.[3] The structure of the sodium and potassium complexes of antibiotics have been repeatedly verified by X-ray crystallography.[4]

In laboratory research, ionophores are used to increase the permeability of biological membranes to certain ions. Additionally, some ionophores are used as antibiotics and/or as growth-enhancing feed additives for certain feed animals, such as cattle (see monensin).[5]

Synthetic ionophores[edit]

Structure of a potassium complex of a crown ether, a synthetic ionophore-ion complex

Most prominent synthetic ionophores are based on crown ethers, cryptands, and calixarenes. These synthetic species are often macrocyclic.[3] Some synthetic agents are not macrocyclic, e.g., carbonyl cyanide-p-trifluoromethoxyphenylhydrazone. Even simple organic compounds, such as phenols, exhibit ionophoric properties.

List of representative biological ionophores[edit]

With the ion(s) they act upon:

See also[edit]

  • Siderophore - Fe3+ binding compounds, found in microbes and grasses


  1. ^ IUPAC, Compendium of Chemical Terminology, 2nd ed. (the "Gold Book") (1997). Online corrected version:  (2006–) "Ionophore".
  2. ^ "Ionophores - MeSH Result". 
  3. ^ a b Greenwood, Norman N.; Earnshaw, Alan (1997). Chemistry of the Elements (2nd ed.). Butterworth-Heinemann. ISBN 0080379419. 
  4. ^ Steinrauf, L. K.; Hamilton, J. A.; Sabesan, M. N. (1982). "Crystal structure of valinomycin-sodium picrate. Anion effects on valinomycin-cation complexes". Journal of the American Chemical Society 104 (15): 4085. doi:10.1021/ja00379a008. 
  5. ^ The US Department of Agriculture sent a letter to Tyson Foods to remove labels for chickens that said "raised without antibiotics" because of the use of ionophores in their feed. Kabel, Marcus; Christine Simmons (2007-11-20). "USDA Revokes OK for Tyson Chicken Labels". Retrieved 2007-11-20. [dead link]
  6. ^ Antonenko, YN; Yaguzhinsky, LS (18 February 1988). "The ion selectivity of nonelectrogenic ionophores measured on a bilayer lipid membrane: nigericin, monensin, A23187 and lasalocid A.". Biochimica et biophysica acta 938 (2): 125–30. PMID 19927398. 

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