Ionotropic glutamate receptor
| Identifiers | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Symbol | Lig_chan | ||||||||
| Pfam | PF00060 | ||||||||
| InterPro | IPR001320 | ||||||||
| SCOP | 1gr2 | ||||||||
| SUPERFAMILY | 1gr2 | ||||||||
| TCDB | 1.A.10 | ||||||||
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The ability of synapses to modify their synaptic strength in response to activity is a fundamental property of the nervous system and may be an essential component of learning and memory. There are three classes of ionotropic glutamate receptor, namely NMDA (N-methyl-D-aspartate), AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole-4-propionic acid) and kainate receptors. They are believed to play critical roles in synaptic plasticity. At many synapses in the brain, transient activation of NMDA receptors leads to a persistent modification in the strength of synaptic transmission mediated by AMPA receptors and kainate receptors can act as the induction trigger for long-term changes in synaptic transmission[1].
This family includes the four transmembrane regions of the ionotropic glutamate receptors and NMDA receptors.
[edit] Subfamilies
[edit] Human proteins containing this domain
GRIA1; GRIA2; GRIA3; GRIA4; GRID1; GRID2; GRIK1; GRIK2; GRIK3; GRIK4; GRIK5; GRIN1; GRIN2A; GRIN2B; GRIN2C; GRIN2D; GRIN3A; GRIN3B; NMDAR2C; NR2A;
[edit] References
- ^ Bortolotto ZA, Clarke VR, Delany CM, Parry MC, Smolders I, Vignes M, Ho KH, Miu P, Brinton BT, Fantaske R, Ogden A, Gates M, Ornstein PL, Lodge D, Bleakman D, Collingridge GL (1999). "Kainate receptors are involved in synaptic plasticity". Nature 402 (6759): 297–301. doi:10.1038/46290. PMID 10580501.
This article incorporates text from the public domain Pfam and InterPro IPR001320
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