Iproclozide

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Iproclozide
Iproclozide.svg
Systematic (IUPAC) name
2-(4-chlorophenoxy)-N'-isopropyl-acetohydrazide
Clinical data
Legal status
  • Uncontrolled
Routes Oral
Identifiers
CAS number 3544-35-2
ATC code N06AF06
PubChem CID 19063
ChemSpider 17998 YesY
UNII 1II9D6CB3J YesY
KEGG D07338 YesY
ChEMBL CHEMBL91238 YesY
Chemical data
Formula C11H15ClN2O2 
Mol. mass 242.70 g/mol
 YesY (what is this?)  (verify)

Iproclozide (trade names Sursum, Sinderesin) is an irreversible and selective monoamine oxidase inhibitor (MAOI) of the hydrazine chemical class that was used as an antidepressant, but has since been discontinued.[1] It has been known to cause fulminant hepatitis and there have been at least three reported fatalities due to administration of the drug.[2][3]

See also[edit]

References[edit]

  1. ^ Suerinck A, Suerinck E. (1966). "[Depressive states in a sanatorium milieu and monoamine oxidase inhibitors. (Therapeutic results by the combination of iproclozide and chlordiazepoxide). Apropos of 146 cases]". Journal de médecine de Lyon 47 (96): 573–586. PMID 5930723. 
  2. ^ Pessayre D, de Saint-Louvent P, Degott C, Bernuau J, Rueff B, Benhamou JP. (1978). "Iproclozide fulminant hepatitis. Possible role of enzyme induction.". Gastroenterology. 75 (3): 492–496. PMID 680506. 
  3. ^ Neil Kaplowitz, Laurie D. DeLeve (2003). Drug-induced liver disease. Informa Health Care. p. 455. ISBN 0-8247-0811-3. ISBN 9780824708115.