Irene Palaiologina
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Irene Palaiologina or Palaeologina (Greek: Ειρήνη Παλαιολογίνα) can refer to:
- Irene Palaiologina, daughter of Michael VIII Palaiologos, Empress-consort of Bulgaria in 1279–80
- Irene Palaiologina, illegitimate daughter of Andronikos II Palaiologos, wife of John II Doukas of Epirus
- Irene Palaiologina of Trebizond, illegitimate daughter of Andronikos III Palaiologos, reigning Empress of Trebizond in 1340–41
- Irene Palaiologina, Empress-consort of Matthew Kantakouzenos
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