Irene Patricia Murphy Keeley (born January 17, 1944) is a United States federal judge.
Born in Brooklyn, New York, Keeley received a B.A. from College of Notre Dame of Maryland in 1965, an M.A. from West Virginia University in 1977, and a J.D. from West Virginia University College of Law in 1980. She was in private practice in Clarksburg, West Virginia from 1980 to 1992, and was an adjunct professor of law at the West Virginia University College of Law from 1990 to 1991.
On April 1, 1992, Keeley was nominated by President George H. W. Bush to a new seat on the United States District Court for the Northern District of West Virginia created by 104 Stat. 5089. She was confirmed by the United States Senate on August 11, 1992, and received her commission on August 12, 1992. She served as chief judge from 2001 to 2008.