Irwin Fridovich
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| Irwin Fridovich | |
|---|---|
| Born | August 2, 1929 New York City |
| Residence | Durham, North Carolina |
| Citizenship | United States |
| Fields | Biochemistry |
| Institutions | Duke University |
| Alma mater | City College of New York, Duke University |
| Doctoral advisor | Philip Handler |
| Doctoral students | Joe M. McCord, Hara P. Misra |
| Known for | superoxide dismutase, oxygen free radicals |
Irwin Fridovich is an American biochemist who, together with his graduate student Joe M. McCord, discovered the enzyme superoxide dismutase (SOD).[1] He is currently Professor emeritus of Biochemistry at Duke University. Superoxide dismutase is a central enzyme for the detoxification of harmful oxygen free radicals (superoxide) formed by the metabolism of organisms. Following the discovery of SOD1, Fridovich also discovered mitochondrial MnSOD (SOD2, now known to be an essential mammalian protein) and spent the rest of his career studying the biochemical mechanisms of biological superoxide toxicity, using bacteria as model systems.[2]
Fridovich received numerous awards and recognitions for his work, including membership in the National Academy of Sciences.
Contents |
[edit] Education
- City College of New York (1951). BS. Major: Chemistry, Minor: Biology
- Cornell Medical College (1951–1952). Department of Medicine - Research Associate
- Duke University (1955). PhD. Department of Biochemistry
[edit] Positions Held
- Duke University - Instructor in Biochemistry, (1956–58)
- Duke University - Associate in Biochemistry, (1958–61)
- Harvard University - Visiting Research Associate, (1961–62)
- Duke University - Assistant Professor of Biochemistry, (1961–66)
- Duke University - Director of Graduate Studies in Biochemistry (1965–67, 1990–92)
- Duke University - Associate Professor of Biochemistry, (1966–71)
- Duke University - Associate Director of Medical Scientist Training Program, (1968–72)
- Duke University - Professor of Biochemistry, (1971–76)
- Duke University - James B. Duke Professor of Biochemistry, (1976–96)
- Duke University - James B. Duke Prof Emeritus (1996–present)
[edit] Editorial Boards, Panels
- National Institutes of Health - Member of Biochemistry StudySection, (1967–71)
- National Board of Medical Examiners - Member (1973–76)
- Journal of Biological Chemistry - Editorial Board, (1971–1976, 1979–1984)
- Life Sciences - Editorial Board, (1975–79)
- Archives of Biochemistry and Biophysics - Editorial Board, (1974–90)
- Analytical Biochemistry - Editorial Board, (1984–present)
- Free Radical Biology and Medicine - Editorial Board, (1984–present)
- Biochemistry - Editorial Board, (1986–present)
- The Biochemical Journal - Editorial Board, (1992–1994)
- Advisory Committee on Biochemistry and Chemical Carcinogenesis, American Cancer Society, (1980–84)
- President, American Society of Biological Chemists, (1982–83)
- President, The Oxygen Society, (1987–1990)
- President, The Society for Free Radical Research, (1992–94)
[edit] Awards
- Predoctoral Research Fellowship, NIH - August, (1954–1955)
- Postdoctoral Research Fellowship, NIH - August, (1955–1956)
- Research Career Development Award, NIH - Jan, (1959–1969)
- Herty Award, Georgia Section, American Chem Society, (1980)
- Founders' Award for Outstanding Research Contributions to Progress in Toxicology, Chemical Industry Institute of Toxicology, (1980)
- Cressy A. Morrison Award in Science, New York Academy of Science, (1984)
- North Carolina Award in Science, (1986)
- Senior Passano Foundation Laureate, (1987)
- Townsend Harris Medal,City College of New York, (1990)
- Elliott Cresson Medal, Franklin Institute, Philadelphia, (1997)
- City of Medicine Award. Durham, North Carolina, (1998)
- Anlyan Lifetime Achievement Award. Duke University, (1998)
- Science & Humanity Prize - 2000 Oxygen Club World Congress, (2000)
[edit] References
- ^ McCord JM, Fridovich I (1988). "Superoxide dismutase: the first twenty years (1968-1988)". Free Radic. Biol. Med. 5 (5–6): 363–9. doi:10.1016/0891-5849(88)90109-8. PMID 2855736.
- ^ Kresge, Nicole; Robert D. Simoni and Robert L. Hill. "Forty Years of Superoxide Dismutase Research: the Work of Irwin Fridovich". The Journal of Biological Chemistry. http://www.jbc.org/content/281/22/e17.full. Retrieved 2011 July 3.
