"Is Anybody Out There?" was produced by Sham & Motesart. Lyrically, the track speaks about self-assurance, separation, and loneliness. K'naan raps about the character Mary, comparing her to American actress Cameron Diaz; “Something ’bout Mary, never won a pageant / Never felt pretty, never looked like Cameron / Diaz was her last name, always been abandoned / Keep your head up baby girl, this your anthem.” It is the second time the duo have collaborated, the first being "Going Away". The video for "Is Anybody Out There?" was directed by Chris Robinson in Toronto, Ontario, Canada during the first week of February. The plot follows a two characters named Mary and Adam. K'naan narrates their journeys through rap. Mary struggles with her appearance and being judged by her peers. Adam struggles with drugs and a father who is never there for him. K'naan and Furtado are shot in a separate scene located in the desolate woods.
"Is Anybody Out There?" obtained mixed reviews by its critics. The track received negative reviews by Jody Rosen of Rolling Stone. Rosen gave the collaboration a mere one and a half out of five stars, criticizing the song's lyrical content. Furtado's vocals and K'naan's rapping were commended by Bill Lamb of About.com, giving the track a positive four out of five stars; however, it was criticized for its lightweight sound.