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Isaac is a given name derived from Judaism and can refer to:
- Isaac, one of the patriarchs of the Jewish, Christian, and Islamic faiths
- Isaac (name), including a list of people with the given name or surname of Isaac and its variants
- Port Isaac, Cornwall, United Kingdom
- Isaac's Harbour, Nova Scotia
- Isaac's Harbour North, Nova Scotia
- International Society for Augmentative and Alternative Communication (ISAAC)
- "Isaac", a song by Madonna, from her album "Confessions on a Dance Floor"
- Isaac, the northeasternmost country in the Fire Emblem universe continent Jugdral, where the video games Fire Emblem: Seisen no Keifu and Fire Emblem: Thracia 776 take place
- Hurricane Isaac (2012), a Category 1 hurricane that hit the Greater New Orleans area on August 29, 2012
- Tropical Storm Isaac (disambiguation), a designation used for various tropical cyclones
- ISAAC (cipher), a cryptographically secure pseudorandom number generator
- ISAAC (comics), a supercomputer in Marvel Comics
- Sacrifice of Isaac (Caravaggio), two paintings by master artist Caravaggio depicting the Biblical scene of the binding of Isaac
- The International Study of Asthma and Allergies in Childhood (ISAAC) A global epidemiological study of asthma and allergies in children
- The Binding of Isaac (video game)
- Isaacs (disambiguation)
- Ishak (disambiguation)
- Izak (disambiguation)
- Zack (disambiguation)
- Izzy (disambiguation)
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