He was the second son of Thomas Astley and Frances Drane, daughter of George Deane. Astley was High Sheriff of Warwickshire in 1641 and High Sheriff of Norfolk in 1645. Having been knighted in 1641, he was created a baronet, of Melton Constable, in the County of Norfolk by King Charles II of England on 21 January 1642.
Astley married firstly Rachel Messenger, daughter of Augustine Messenger, and secondly Bridget Coke, daughter of John Coke. Both marriages were childless. Astley was buried in Melton Constable in Norfolk and with his death the baronetcy became extinct. The heir of his estates was his nephew Sir Jacob Astley, 1st Baronet.
- "Leigh Rayment - Baronetage". Retrieved 9 June 2009.
- Burke, John (1832). A Genealogical and Heraldic History of the Peerage and Baronetage of the British Empire. vol. I (4th ed.). London: Henry Colburn and Richard Bentley. p. 51.
- "ThePeerage - Sir Isaac Astley, 1st and last Bt". Retrieved 5 January 2007.
- Burke, John (1841). John Bernhard Burke, ed. A Genealogical and Heraldic History of the Extinct and Dormant Baronetcies of England, Ireland and Scotland (2nd ed.). London: Scott, Webster, and Geary. p. 23.
|Baronetage of England|
(of Melton Constable)
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