His grandfather was one of a group of leadminers who left Cornwall for Wales and settled in Flintshire. Isaac's father Edward moved to Rhosllannerchrugog from Holywell, Flintshire as an apprentice grocer and, later, set up his own grocers and drapery shop in Rhos.
During his lifetime he published only one collection, Cerddi a Baledi, in 1936 but a second collection of his work, Y Gwin a Cherddi Eraill, was published after his death in 1948. Hooson is best known for his poems written for children and he also wrote a Welsh language adaptation of The Pied Piper of Hamelin under the title Y Fantell Fraith in 1934.
A memorial to I. D. Hooson was erected on the Panorama, near Llangollen.