Isaac Goodale House is a historic colonial house at 153 Argilla Road in Ipswich, Massachusetts. The house has many First Period elements, including a prominent central chimney, steep pitched roof, unpainted clapboards and trim, diamond-shaped lead-paned casement windows, and board and batten doors. It is 3,421 square feet, with 5 fireplaces, 4 bedrooms, 3 bathrooms, and is located on a 41 acre woodland property that borders salt marsh on one side and an apple orchard on another.
It was built in c. 1668 by Robert Goodale of Salem for his son Isaac upon Isaac's marriage in 1668. Originally located in Salem, Massachusetts, the house was moved to Ipswich by a Goodale family member in 1928. The house was added to the National Register of Historic Places in 1990. It was rented by the Peterson family from 1997 to 2007. Then, after 340 years of almost continuous family ownership, the house and 41 acres (17 ha) of land went up for sale with an asking price of $1.39 million. It was bought in 2010 by the Duffield family.