Isaac Roach (February 24, 1786 – December 29, 1848) was an American lawyer and politician who served one term as mayor of Philadelphia, from 1838 to 1839. He was a captain in the United States Army and fought in the War of 1812. He was brevetted to Major in April 1823,  and resigned from the army on April 1, 1824. He became the mayor of Philadelphia in 1838 and was later appointed the Treasurer of the Mint.
On October 4, 1819, Roach married Mary Huddell.
Roach died in 1848 in Philadelphia, where he is buried in St. Peter's churchyard.
- Stryker's American Register and Magazine. W.M. Morrison. 1849. p. 251.
- Jenkins, Howard Malcolm; Seilhamer, George Overcast (1895). Memorial History of the City of Philadelphia, from Its First Settlement to Year 1895. Harvard University: New York History Co. p. 499.
- The Pennsylvania Magazine of History and Biography. University of Michigan: Historical Society of Pennsylvania. 1893. p. 129. ISSN 0031-4587.
- Simpson, Henry (1859). The Lives of Eminent Philadelphians, Now Deceased. W. Brotherhead. p. 847.
- Mackenzie, George Norbury; Rhoades, Nelson Osgood (1917). Colonial Families of the United States of America. University of Wisconsin–Madison: The Grafton Press. p. 386.
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