Pinto was a man of broad learning, but did not begin to write until nearly fifty, when he acquired a reputation by defending his co-religionists against Voltaire. In 1762 he published his Essai sur le Luxe at Amsterdam. In the same year appeared his Apologie pour la Nation Juive, ou Réflexions Critiques. The author sent a manuscript copy of this work to Voltaire, who thanked him. Antoine Guenée reproduced the Apologie at the head of his Lettres de Quelques Juifs Portugais, Allemands et Polonais, à M. de Voltaire.
In 1763 De Pinto became bankrupt as a result of speculation; he had to sell his house on Nieuwe Herengracht with five famous fixed wall-paintings by Jan Weenix. De Pinto moved to another fine mansion in The Hague; he and his family were invited to the palace when Mozart and his sister played. In 1768, Pinto sent a letter to Diderot on Du Jeu de Cartes. His Traité de la Circulation et du Crédit appeared in Amsterdam in 1771, and was twice reprinted, besides being translated into English and German. His Précis des Arguments Contre les Matérialistes was published at The Hague in 1774. Pinto's works were published in French (Amsterdam, 1777) and also in German (Leipzig, 1777).