Portrait of Isabella Clark
|Died||28 December 1857|
|Known for||Wife of John A. Macdonald|
Isabella Macdonald, née Clark (1811 – 28 December 1857) was the first wife of John A. Macdonald, one of the fathers of the Canadian federation. The couple were related by sharing their maternal grandmother; cousin marriage was not uncommon then.
During their marriage, he became the premier of the Province of Canada in 1856.
She became ill after just two years of marriage, and developed an addiction to opium mixed with wine (Laudanum). She bore two sons: John, who died at 13 months, and Hugh, who grew up to be a politician too.
After her death in 1857, medical examination concluded that she was suffering from a somatization disease.