When Isabella was only two years old, her mother was placed under house arrest because it was thought she was having love affairs. Joan was released the following year since Isabella's father, Philip refused to divorce her. Her aunt, Blanche of Burgundy had been imprisoned in the fortress of Château Gaillard in 1314 along with Isabella's other aunt, Margaret of Burgundy.
Isabella married Guigues VIII of Viennois in 1323 (the marriage was contracted in Lyon on 18 June 1316 and made in Dole on 17 May 1323). The marriage produced one son,