Before Indian independence in 1947, Isagarh was part of the princely state of Gwalior, where it was the administrative headquarters of Isagarh District. After Indian independence, Gwalior state became part of the new Indian state of Madhya Bharat, and Isagarh District was renamed Guna District. Madhya Bharat was merged into Madhya Pradesh on November 1, 1956. Guna District was split into the districts of Guna and Ashoknagar on August 15, 2003.
As of 2001[update] India census, Isagarh had a population of 35,347. Males constitute 53% of the population and females 47%. Isagarh has an average literacy rate of 62%, higher than the national average of 59.5%: male literacy is 72%, and female literacy is 50%. In Isagarh, 18% of the population is under 6 years of age.