Isobutyryl-CoA mutase

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isobutyryl-CoA mutase
Identifiers
EC number 5.4.99.13
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, an isobutyryl-CoA mutase (EC 5.4.99.13) is an enzyme that catalyzes the chemical reaction

2-methylpropanoyl-CoA \rightleftharpoons butanoyl-CoA

Hence, this enzyme has one substrate, 2-methylpropanoyl-CoA, and one product, butanoyl-CoA.

This enzyme belongs to the family of isomerases, specifically those intramolecular transferases transferring other groups. The systematic name of this enzyme class is 2-methylpropanoyl-CoA CoA-carbonylmutase. Other names in common use include isobutyryl coenzyme A mutase, and butyryl-CoA:isobutyryl-CoA mutase. It has 2 cofactors: cobalt, and Cobamide coenzyme.

References[edit]

  • Willenbrock F and Robinson JA (1988). "The enzymic interconversion of isobutyryl and N-butyrylcarba(dethia)-coenzyme-A - a coenzyme-B12-dependent carbon skeleton rearrangement". Angew. Chem. Int. Ed. Engl. 27 (8): 1089–1091. doi:10.1002/anie.198810891.