From Wikipedia, the free encyclopedia
Jump to: navigation, search
Isoguanine vector.svg
CAS number 3373-53-3
PubChem 76900
ChemSpider 69351
EC number 222-157-6
Jmol-3D images Image 1
Molecular formula C5H5N5O
Molar mass 151.1261
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
Infobox references

Isoguanine or 2-hydroxyadenine is a purine base that is an isomer of guanine. It is a product of oxidative damage to DNA and has been shown to cause mutation.[1] It is also used in combination with isocytosine in studies of unnatural nucleic acid analogues of the normal base pairs in DNA.



  1. ^ Yang XL, Sugiyama H, Ikeda S, Saito I, Wang AH (1998). "Structural studies of a stable parallel-stranded DNA duplex incorporating isoguanine:cytosine and isocytosine:guanine basepairs by nuclear magnetic resonance spectroscopy". Biophys. J. 75 (3): 1163–71. doi:10.1016/S0006-3495(98)74035-4. PMC 1299791. PMID 9726918.