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CAS number 1003-07-2 YesY
PubChem 96917
ChemSpider 87509 N
MeSH C001490
Jmol-3D images Image 1
Image 3
Molecular formula C3H3NOS
Molar mass 101.127
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N (verify) (what is: YesY/N?)
Infobox references

Isothiazolinone is a heterocyclic chemical compound. Derivatives of isothiazolinone are used as biocides, including:

The derivative butylbenzisothiazolinone (BBIT) also exists, but does not have the same importance.


Isothiazolinones are antimicrobials used to control bacteria, fungi, and algae in cooling water systems, fuel storage tanks, pulp and paper mill water systems, oil extraction systems, wood preservation and antifouling agents. They are frequently used in personal care products such as shampoos and other hair care products, as well as certain paint formulations. Often, combinations of MIT and CMIT (known as Kathon CG) or MIT and BIT are used.

Biological implications[edit]

Together with their wanted function, controlling or killing microorganisms, isothiazolinones also have undesirable effects: They have a high aquatic toxicity and some derivatives (namely CMIT) can cause hypersensitivity by direct contact or via the air.