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Skeletal formula of isovaleramide
Ball-and-stick model of isovaleramide
CAS number 541-46-8 YesY
PubChem 10930
ChemSpider 10467 N
EC number 208-781-1
KEGG D04637 YesY
Jmol-3D images Image 1
Molecular formula C5H11NO
Molar mass 101.15 g mol−1
Appearance colourless solid
Melting point 137 °C (279 °F; 410 K)
Boiling point 226 °C (439 °F; 499 K)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N (verify) (what is: YesY/N?)
Infobox references

Isovaleramide is an organic compound with the formula (CH3)2CHCH2C(O)NH2. The amide derived from isovaleric acid, it is a colourless solid.

Occurrence and biological activity[edit]

Isovaleramide is found in the Valerian root.

In humans, it acts as a mild anxiolytic at lower doses and as a mild sedative at higher dosages.[1] Isovaleramide has been shown to be non-cytotoxic and does not act as a CNS stimulant. It inhibits the liver alcohol dehydrogenases and has a reported LD50 of greater than 400 mg/kg when administered intraperitoneally in mice.[2]


  1. ^ "Use of isovaleramide as a mild anxiolytic and sedative agent", US 5506268 
  2. ^ Taillandier, Georges; Benoit-Guyod, Jean L.; Boucherle, Andre; Broll, Madeleine; Eymard, Pierre (1975). "Dipropylacetic series. XII. Anticonvulsant branched aliphatic acids and alcohols". European Journal of Medicinal Chemistry 10 (5): 453–462.