Isovaleric acid amide
|Molar mass||101.15 g·mol−1|
|Melting point||137 °C (279 °F; 410 K)|
|Boiling point||226 °C (439 °F; 499 K)|
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
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Occurrence and biological activity
Isovaleramide is found in the Valerian root.
In humans, it acts as a mild anxiolytic at lower doses and as a mild sedative at higher dosages. Isovaleramide has been shown to be non-cytotoxic and does not act as a CNS stimulant. It inhibits the liver alcohol dehydrogenases and has a reported LD50 of greater than 400 mg/kg when administered intraperitoneally in mice.
- "Use of isovaleramide as a mild anxiolytic and sedative agent", US 5506268
- Taillandier, Georges; Benoit-Guyod, Jean L.; Boucherle, Andre; Broll, Madeleine; Eymard, Pierre (1975). "Dipropylacetic series. XII. Anticonvulsant branched aliphatic acids and alcohols". European Journal of Medicinal Chemistry 10 (5): 453–462.