The song received generally mixed to positive reviews from contemporary music critics, who compared Harrison to her contemporary peers Brandy and Monica. "It’s All About Me" became a Top Ten hit on Billboard's Hot 100 for the week of May 16, 1998; peaking and spending three consecutive weeks at number six. It fared better on the component Hot R&B Singles chart, reaching number two. Internationally, the single was a modest success; it reached the Top 20 in New Zealand and the Top 40 in Canada.
The song’s accompanying music video was filmed by director G. Thomas Ferguson and University Music CEO Haqq Islam. Harrison choreographed the dance routines and designed her own outfit - a red Japanese traditional kimono. The music video featured Harrison performing a strip tease and fencing with Sisqó after they meet following a concert from Sisqó's group, Dru Hill (Harrison, Sisqó, and Dru Hill were all label mates at the time on University Music).
In an interview with Rolling Stone magazine, Harrison described the concept behind "It’s All About Me": "It's not a conceited thing. Basically, I'm speaking for people who are in relationships but aren't getting their fifty percent. The song is about taking control. Personally, I'm not trying to get into relationships right now. But when I do, it's fifty-fifty."
Billboard magazine gave the song a positive review:
"Although It's All About Me can be too repetitive and thus unnecessarily tiring at times, it does have an interesting, catchy rhythm that's hard to miss. Undoubtedly, R&B listeners will find this highly appealing. The vocals have a great range, as well as a smooth, angelic tone. It's worth giving it a try."
In the United States, It’s All About Me debuted at number eighty-two on BillboardHot 100 chart for the issue dated week of March 14, 1998. It ascended from 82-62 in its second week for the issue dated week of March 21, 1998. The song reached its peak at number six for issue dated week of May 16, 1998. From the issue dated weeks of May 16–30, 1998; it spent 3 consecutive weeks at number six. It spent a total of 20 consecutive week on the chart. The single became Harrison’s first consecutive Top Ten hit (solo) on the chart and was certified gold by Recording Industry Association of America on June 4, 1998 selling 800,000 copies. It became a Top Five hit on Billboard’s component chart Hot R&B Singles chart. It debuted at number sixty-one for the issue dated week of March 14, 1998. It rose from 61-31 in its second week for the issue dated week of March 21, 1998. It’s All About Me entered the coveted Top Ten at number eight for issue dated week of April 18, 1998. It reached its peak at number two the issue dated week of May 9, 1998. The song spent a total of 27 consecutive weeks on the chart. It's All About Me remains Harrison's biggest and highest charting single to date on the Hot R&B Singles chart.
In Canada, the song reached its peak at number thirty-nine for the issue dated week of April 25, 1998. It spent a total of 6 consecutive weeks on the chart. It’s All About Me debuted at number twenty-seven during the week of June 21, 1998 in New Zealand. It reached its peak at number thirteen during the week of July 19, 1998. It spent a total of 15 consecutive weeks on the chart.
In an interview with MTV News, Mýa talked about the concept behind the video for "All About Me," on which Sisqó reprises his smooth-talkin', ladies man role. "Sisqó pulls me out of the crowd," Mýa said, "because I guess I look uninterested, and that's not common, y'know to have people uninterested in such big stars. So, he pulls me out thinking he's gonna make me his lady of the night." "Through the dance and the whole video," she continued, "I tease him and say, 'No, I'm not that kind of girl and if you wanna be with me, you have to make it all about me.'"