"It Kills Me" is the title of an R&B single by Melanie Fiona and the second U.S. single (third in Canada after "Give It to Me Right" and "Bang Bang") from The Bridge. The track spent nine weeks at number-one on the US Billboard R&B singles chart. The track would also peak just outside of the Top 40 on the Billboard Hot 100, peaking at 43. Fiona received a Grammy nomination in the category of Best Female R&B Vocal Performance for the track, however the Grammy was awarded to Beyoncé for "Single Ladies (Put a Ring on It)". The song samples "(Hey There) Lonely Girl" by The Softones.
The official remix features rapper Ghostface Killah.