He journeyed to Austria and created several multi-panel altarpieces there in 1500–02, such as the Melk Altar (1502). He returned to Augsburg in 1502 where he became a master. He travelled to Italy twice, in ca. 1508 and in 1514/15.
After his death in 1537, his son, Jörg Breu the Younger continued to lead his Augsburg workshop until his own death 10 years later.