From Wikipedia, the free encyclopedia
Jump to: navigation, search
Jagged 1
Protein JAG1 PDB 2KB9.png
Rendering based on PDB 2KB9.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols JAG1 ; AGS; AHD; AWS; CD339; HJ1; JAGL1
External IDs OMIM601920 MGI1095416 HomoloGene180 GeneCards: JAG1 Gene
RNA expression pattern
PBB GE JAG1 216268 s at tn.png
PBB GE JAG1 209097 s at tn.png
PBB GE JAG1 209098 s at tn.png
More reference expression data
Species Human Mouse
Entrez 182 16449
Ensembl ENSG00000101384 ENSMUSG00000027276
UniProt P78504 Q9QXX0
RefSeq (mRNA) NM_000214 NM_013822
RefSeq (protein) NP_000205 NP_038850
Location (UCSC) Chr 20:
10.62 – 10.65 Mb
Chr 2:
137.08 – 137.12 Mb
PubMed search [1] [2]

JAG1 is a protein associated with Alagille syndrome. JAG1 has also been designated as CD339 (cluster of differentiation 339).

The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor Notch-1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis.[1]


JAG1 has been shown to interact with NOTCH2.[2][3][4]

See also[edit]


  1. ^ "Entrez Gene: JAG1 jagged 1 (Alagille syndrome)". 
  2. ^ Shimizu, K; Chiba S; Saito T; Kumano K; Takahashi T; Hirai H (July 2001). "Manic fringe and lunatic fringe modify different sites of the Notch2 extracellular region, resulting in different signaling modulation". J. Biol. Chem. (United States) 276 (28): 25753–8. doi:10.1074/jbc.M103473200. ISSN 0021-9258. PMID 11346656. 
  3. ^ Shimizu, K; Chiba S; Kumano K; Hosoya N; Takahashi T; Kanda Y; Hamada Y; Yazaki Y; Hirai H (November 1999). "Mouse jagged1 physically interacts with notch2 and other notch receptors. Assessment by quantitative methods". J. Biol. Chem. (UNITED STATES) 274 (46): 32961–9. doi:10.1074/jbc.274.46.32961. ISSN 0021-9258. PMID 10551863. 
  4. ^ Shimizu, K; Chiba S; Hosoya N; Kumano K; Saito T; Kurokawa M; Kanda Y; Hamada Y; Hirai H (September 2000). "Binding of Delta1, Jagged1, and Jagged2 to Notch2 Rapidly Induces Cleavage, Nuclear Translocation, and Hyperphosphorylation of Notch2". Mol. Cell. Biol. (UNITED STATES) 20 (18): 6913–22. doi:10.1128/MCB.20.18.6913-6922.2000. ISSN 0270-7306. PMC 88767. PMID 10958687. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.